Local increase of IgE in nasal polyps in eosinophilic chronic rhinosinusitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791747
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: The University of Tokyo
• Principal Investigator: BABA Shintaro 東京大学, 医学部附属病院, 届出診察医 (90553719)
• Co-Investigator(Kenkyū-buntansha): KONDO Kenji 東京大学, 医学部附属病院, 講師 (40334370) ; SUZUKAWA Keigo 東京大学, 医学部附属病院, 助教 (50447398) ; SUZUKAWA Maho 帝京大学, 内科 (20453699) ; USHIO Munetaka 東京大学, 医学部附属病院, 助教 (70361483) ; KANAYA Kaori 東京大学, 医学部附属病院, 助教 (90456129) ; YAMASOBA Tatsuya 東京大学, 医学部附属病院, 教授 (60251302)
• Co-Investigator(Renkei-kenkyūsha): OOTA Ken 帝京大学, 内科, 教授 (30160500)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 副鼻腔炎 / 好酸球 / ＩｇＥ / クラススイッチ

Outline of Final Research Achievements

Background: Chronic rhinosinusitis with nasal polyps is generally characterized by local Th2 inflammation and is categorized into two subtypes in Japan: eosinophilic chronic rhinosinusitis (similar to chronic rhinosinusitis with nasal polyps in western countries), and non eosinophilic chronic rhinosinusitis (characterized by Th1-dominant inflammation). Objective: To investigate local IgE production and class switch recombination to IgE in these two subtypes of chronic rhinosinusitis with nasal polyps. Conclusion: The current study suggests local class switching to IgE, production of IgE, and IgE localization to the surface of mast cells in eosinophilic chronic rhinosinusitis in the Japanese population. The difference in the IgE-related profiles between eosinophilic chronic rhinosinusitis and non-eosinophilic chronic rhinosinusitis suggests heterogeneity in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Free Research Field

鼻科学