2013 Fiscal Year Final Research Report
Studies of basic research about inner ear homeostasis of Meniere' s disease
| Project/Area Number |
24791748
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
EGAMI Naoya 東京大学, 医学部附属病院, 助教 (10505895)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | メニエール病 / 内リンパ水腫 / 抗利尿ホルモン / アクアポリン |
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| Research Abstract |
The purpose of this study was to clarify the underlying mechanism of vertiginous attacks in Ménière's disease (MD) with a new combined animal model. Our animal model induced severe endolymphatic hydrops (EH) in the cochlea and the saccule and showed episodes of balance disorder along with spontaneous nystagmus. These findings suggest that administration of vasopressin (VP) can exacerbate EH due to acute V2; VP type 2 receptor-mediated effects, and when combined with endolymphathic sac (ES) dysfunction can cause temporary vestibular abnormalities that are similar to the vertiginous attacks in patients with MD.Systemic or local application of VP type 2 receptor antagonistist; V2 antagonist (OPC-41061), an inhibitor of the VP-AQP2 reduced EH in the cochlea and the saccule.
These results suggest that VP-AQP2 system plays an important role in the pathogenesis of MD and an inhibitor of the VP-AQP2 system will be a promising drug in the treatment of MD.
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