the therapeutic resistant mechanisms of head and neck cancer stem cells

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791773
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: FUKUSUMI Takahito 大阪大学, 医学部附属病院, 医員 (70623734)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 癌幹細胞 / CD10 / 頭頸部扁平上皮癌 / 抗癌剤耐性 / 放射線耐性 / 細胞周期 / 抗体アレイ

Research Abstract

Radiotherapy and chemotherapy initially control tumour growth in head and neck cancer. However, over time many patients suffer relapse. To improve prognosis, the establishment of a novel marker to predict therapeutic resistance is required. It is currently understood that cancer stem cells (CSCs) are responsible for treatment failure in a diversity of cancers. In the present study,sis and testing of cell viability in the presence of therapeutic agents, we identified CD10 as a potential marker of refractory HNSCC. Moreover, CD10 was found to confer a CSC-like phenotype, and underscored expression of OCT3/4. Thus, CD10 could be a specific marker of HNSCC CSCs that contributes to therapeutic resistance. These results were accepted by the British Journal of Cancer in 2014.

Research Products

• [Journal Article] CD10 as a novel marker of therapeutic resistance and cancer stem cells in head and neck squamous cell carcinoma
  • Author(s): Takahito Fukusumi, et al
  • Journal Title: British Journal of Cancer Volume: (in press)
  • Peer Reviewed
• [Presentation] CD10 positive head and neck squamous cell carcinoma have therapeutic resistance and cancer stem cell features (2013)
  • Author(s): 福角隆仁, 石井秀始, 今野雅允, 西川晋平, 加納義浩, 長谷川慎一郎, 小川久貴, 浜部敦史, 佐藤太郎, 土岐祐一郎, 森正樹, 猪原秀典
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-05
• [Presentation] CD10 Positive Head and Neck Squamous Cell Carcinoma Have Chemo-resistant and Radio-resistant Properties (2013)
  • Author(s): Takahito Fukusumi, Shimpei Nishikawa, Yoshihiro Kano, Katsuya Ohta, Shinichiro Hasegawa, Hisataka Ogawa, Atsushi Hamabe, Masamitsu Konno, Naotsugu Haraguchi, Taroh Satoh, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Hidenori Inohara
  • Organizer: American Association for Cancer Research annual meeting
  • Place of Presentation: Washington DC
  • Year and Date: 20130405-10
• [Presentation] 新規頭頸部扁平上皮癌幹細胞マーカーの検索 (2012)
  • Author(s): 福角隆仁, 原口直紹, 西川晋平, 加納義浩, 佐藤太郎, 石井秀始, 土岐祐一郎, 森正樹, 猪原秀典
  • Organizer: 第71回 日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 抗体アレイを用いた新たな頭頸部癌幹細胞マーカーの検討 (2012)
  • Author(s): 福角隆仁, 花本敦, 安井俊道, 中原晋, 竹中幸則, 山本佳史, 原口直紹, 石井秀始, 土岐祐一郎, 森正樹, 猪原秀典
  • Organizer: 第36回日本頭頸部癌学会
  • Place of Presentation: 島根
  • Year and Date: 20120607-08