2013 Fiscal Year Final Research Report
Participation of cytokine in the proliferative change in retina of POMGnT1-deficient mice
| Project/Area Number |
24791881
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | POMGnT1 / VEGF / PDGF |
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| Research Abstract |
In retina and vitreous body of POMGnT1-deficient mice which was a model mouse of Muscle-Eye-Brain disease, We analyzed expression of various cytokine and tried elucidation of the mechanism that an astrocytic abnormal increase produced. As a result of immunohistochemistry for VEGF, HGF, and PDGF, it was recognized that the expression of VEGF and PDGF-A in retinal surface and vitreous bodies of POMGnT1-deficient mice was increased.
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