2014 Fiscal Year Final Research Report
Glaucoma and oxidative stress
| Project/Area Number |
24791882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 緑内障 / 酸化ストレス / 線維柱帯細胞 / 緑内障点眼薬 / 分子生物学 / 転写 |
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| Outline of Final Research Achievements |
Glaucomatous TM cells highly express sirt1 when compared with normal TM cells. Tafluprost induces the expression of sirt1 through the activation of the c-mic transcription factor. TM cells showed reduced sensitivity to H2O2 when cells were treated with tafluprost. In addition, both transcription factor c-myc and sirt1 expression was enhanced by drug induced signal transduction through its receptor.
These results indicate that tafluprost possesses a novel mechanism of action and function as potent protective agents against oxidative stress.
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| Free Research Field |
緑内障
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