2013 Fiscal Year Final Research Report
Evaluation of the utility of growth factors for the treatment of hypertrophic scar
| Project/Area Number |
24791919
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Kyorin University |
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Principal Investigator |
ETO Hitomi 杏林大学, 医学部, 助教 (40612594)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 線維芽細胞 / 増殖因子 / 瘢痕治療 |
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| Research Abstract |
To evaluate the utility of basic fibroblast growth factor (bFGF) for the treatment of hypertrophic scar, we investigated the effects on cultured fibroblasts of bFGF. On the basis of the findings that dermal fibroblast is mixed population consisted of some subpopulations having differing characteristics, superficial fibroblasts, which express anti-fibrotic factors, and deep fibroblasts, which express pro-fibrotic factors, were isolated and analysed by microarray and real-time PCR. Basic FGF were elucidated to increase the expression of specific factor for superficial fibroblasts, suggesting enhance the capability of the cells to suppress fibrosis.
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