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2014 Fiscal Year Final Research Report

Immunophenotyping for detecting susceptibility to infection and organ failure in critically ill patients

Research Project

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Project/Area Number 24791953
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionKeio University

Principal Investigator

TAMURA Tomoyoshi  慶應義塾大学, 医学部, 助教 (00571720)

Research Collaborator SEKINE Kazuhiko  慶應義塾大学, 医学部, 研究員 (90296715)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords白血球表面抗原 / プロテインアレイ法 / 重症患者 / 敗血症性ショック / 多発外傷 / 広範囲熱傷
Outline of Final Research Achievements

Critically ill patients often die of multiple organ failure following infection. Immunophenotyping (IP) method, a novel analysis system of diverse leukocyte surface antigens using the protein array method for evaluation of host immunological status, was sufficiently implemented in timely manner by bedside in critically ill patients. After the onset of organ failure, CD4 and CD36 decreased, CD16b and CD66b increased, respectively. Proportion of CD4 and the severity of the organ failure were inversely related in septic shock patients. The rapid bedside analysis of diverse leukocyte subsets with our IP method was applicable and could be useful for predicting organ failure in critically ill patients.

Free Research Field

救急医学、集中治療

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Published: 2016-06-03  

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