Analysis of bone healing process with the in vivo targeting system of NFkB decoy

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791959
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: Nakamura Megumi 東北大学, 歯学研究科(研究院), 助教 (20431512)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 骨修復 / 炎症 / NF-κB / 規格化骨欠損

Outline of Final Research Achievements

This study was designed to investigate bone healing process of the standardized calvarial defect in rats with downregulation of inflammation-related molecules by nuclear factor-kappa B (NFkB) decoy to elucidate the role of inflammation in bone repair. So far, we succeeded to establish the in vivo targeting system using type I collagen sponge as a carrier. In addition, we showed the mRNA expression of proinflammatory cytokines in developing bone of which bone formation process is comparable to that of healing bone.

Free Research Field

組織・発生学