2013 Fiscal Year Final Research Report
The analysis of novel virulence proteins Tap secreted by Porphyromonas gingivalis
| Project/Area Number |
24791964
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
KONDO Yoshio 長崎大学, 医歯(薬)学総合研究科, 助教 (30581954)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 歯学 / 歯周病 / Porphyromonas gingivalis |
|---|
| Research Abstract |
Porphyromonas gingivalis is one of the most etiologically important microorganisms in periodontal disease. Although many studies have reported about virulence factors of P. gingivalis, expression of P. gingivalis in in vivo lesion is not completely understood. We reported in a previous study that TprA, TapA, TapB and TapC proteins are cooperatively involved in P. gingivalis virulence. However, function of these proteins are not certain. Then we focused on surface proteins TapA and TapC and investigated for effect to host cells.
|
