2014 Fiscal Year Final Research Report
A novel preventive technique of dental diseases based on photo-dynamic anti-microbial therapy utilizing plaque discolinsg liquid
| Project/Area Number |
24791977
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 光線力学療法 / 殺菌 / 一重項酸素 / 水酸化ラジカル / プラーク染色剤 / ポリフェノール |
|---|
| Outline of Final Research Achievements |
Dyes contained in plaque disclosing liquid can be activated by photo-irradiation with a specific wavelength. The activated dyes generate singlet oxygen, a type of reactive oxygen species, when they return to the ground state. Since singlet oxygen has strong oxidative effect, it exerts bactericidal activity when reacts with bacteria. In the present study, it was demonstrated that the photodynamic antimicrobial therapy exerted strong bactericidal action on cariogenic bacteria (Streptococcus mutans). In addition, it was found that photo-irradiation of polyphenol aqueous solution also exerted bactericidal effect. Thus, it is suggested that this technique can be used a novel photodynamic antimicrobial therapy.
|
| Free Research Field |
医歯薬学
|
