2013 Fiscal Year Final Research Report

The association between the sialoadenitis and the abnormality of B cells of patients with Sjogren's syndrome.

Research Project

Project/Area Number	24791992
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Hokkaido University
Principal Investigator	NAKAGAWA Yasuko 北海道大学, 歯学研究科(研究院), 研究員 (80451392)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	シェーグレン症候群 / B細胞 / Act1
Research Abstract	B cell hyper-activation is a predominant feature of Sjögren's syndrome (SS) related to production of autoantibodies. The adaptor molecule Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling. Act1-deficient mice develop autoimmune manifestations similar to SS. In this study, to investigate the role of Act1 in the pathogenesis of SS, we examined Act1 mRNA expressions in B cells from patients with SS and discussed the association of Act1 with parameters and clinical manifestations of SS include sialoadenitis. We showed the low level of Act1 mRNA expression in patients with SS and reciprocal association of Act1 with serum IgG level. The MSG had low Act1 mRNA expression levels tended to be increased B cell and plasma cell infiltration. Diminished Act1 mRNA expression in SS may be associated with B cell hyperactivity and elevated immunoglobulin production in SS by uncontrolled B cell activation signal through CD40 and BAFFR.

(1 results)