2014 Fiscal Year Final Research Report
Functional analysis of oral cancer stem cell related gene, SPRR1B
| Project/Area Number |
24792005
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 口腔がん / がん幹細胞 / SPRR1B |
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| Outline of Final Research Achievements |
We isolated oral cancer stem-like cells(CSCs)/cancer-initiating cells(CICs) by aldefluor assay. A cDNA microarray analysis revealed that SPRR1B is preferentially expressed in oral CSCs/CICs. Gene overexpression and gene knockdown experiments revearled that SPRR1B has a role in the cell growth of oral CSCs/CICs by activation of RAS signal. These observations indicate that SPRR1B might be a promising molecular target for treatment resistant oral CSCs/CICs.
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| Free Research Field |
腫瘍学
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