2014 Fiscal Year Final Research Report
The effects of lysophosphatidic acid on osteoclast activity.
| Project/Area Number |
24792009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | メカニカルストレス / ATP / P2X7 / 骨芽細胞 |
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| Outline of Final Research Achievements |
LPA stimulated the expression of IL-1beta in osteoclast precursor cell line RAW 264.7. LPA-induced IL-1beta also enhanced osteoclast survival.
Mechanical stimuli such as Low-intensity pulsed ultrasounds (LIPUS) and tension force (TF) induced extracellular ATP release. Mechanical stimuli-induced ATP activated P2X7 receptor increased extracellular matrix proteins and bone formation. However, LIPUS enhanced bone formation without the increases of ALPase activity.
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| Free Research Field |
細胞生物学
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