2013 Fiscal Year Final Research Report
Elucidation of the mechanism of dentin regeneration focused on reprogramming of human dental pulp cells mediated by TNF-alpha
| Project/Area Number |
24792084
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Prosthetic dentistry
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
UEDA Mayu 岡山大学, 大学病院, 医員 (20625719)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | TNF-α / 歯髄細胞 / 幹細胞化 |
|---|
| Research Abstract |
The purpose of this study is to investigate the effects of a treatment with TNF-alpha on the stem cell phenotype and differentiation ability of human dental pulp cells, and elucidate of the mechanism of dentin regeneration.
In conclusion, our data show that a short-term treatment with TNF-alpha significantly increases the stem cell phenotype of DPCs as well as their function and multipotent differentiation ability. Additionally, our findings also demonstrate that the reprogramming depend on TNF-alpha specifically and NF-kB is not the only pathway involved in the TNF-alpha-enhanced stem cell phenotype of DPCs.
|
