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2013 Fiscal Year Final Research Report

A search and evaluation of the peptides that control the connective tissue growth factor for the prevention and the treatment of osteoarthritis.

Research Project

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Project/Area Number 24792142
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOkayama University

Principal Investigator

OIDA Yasutaka  岡山大学, 大学病院, 医員 (50625720)

Research Collaborator KUBOKI Takuo  岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 教授
SONOYAMA Wataru  岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 講師
ONO Mitsuaki  岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 助教
ハラ エミリオ サトシ  岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 助教
SHINKAWA Shigehiko  岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 医員
NAKAJIMA Ryu  岡山大学, 大学院・医歯薬学総合研究科インプラント再生補綴学分野, 大学院生
Project Period (FY) 2012-04-01 – 2014-03-31
Keywordsハルミン / CCN2 / β-カルボリン / 軟骨細胞 / 軟骨再生
Research Abstract

CCN2 / connective tissue growth factor (CTGF) has been reported to have essential role in cartilage development, chondrocyte proliferation and differentiation as well as regulation of the extracellular matrix metabolism. This study screened a compound library and identified harmine as a novel inducer of CCN2. This finding indicates harmine as a potential drug for prevention and / or repair of cartilage degradation.

  • Research Products

    (7 results)

All 2013 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Novel chodrogenic and chondroprotective effects of the natural compound harmine2013

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
    • Journal Title

      Biochimie

      Volume: 95巻 Pages: 374-381

    • DOI

      10.1016/j.biochi.2012.10.016

    • Peer Reviewed
  • [Presentation] The CCN2-inducer Harmine promotes chondrogenesis and protection against TNFα-induced inflammation2011

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
    • Organizer
      第59 国際歯科研究学会日本部会 (JADR) 総会・学術大会- Hatton award competition
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-10-08
  • [Presentation] The CCN2-inducer Harmine promotes chondrogenesis and protection against TNFα-induced inflammation2011

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
    • Organizer
      第59国際歯科研究学会日本部会 (JADR) 総会・学術大会
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2011-10-08
  • [Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and rescues TNF-α-induced downregulation of cartilage markers2011

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Hattori T, Nishida T, Takigawa M, Kuboki T
    • Organizer
      第2骨バイオサイエンス研究会
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2011-08-28
  • [Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and protection against TNF-α-induced inflammatory condition2011

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
    • Organizer
      第4日本CCNファミリー研究会
    • Place of Presentation
      Okayama, Japan
    • Year and Date
      2011-08-28
  • [Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and suppresses TNF-α-induced inflammatory response2011

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Hattori T, Takigawa M, Kuboki T
    • Organizer
      第29日本骨代謝学会
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2011-07-29
  • [Presentation] Novel chondroprotective and anti-inflammatory effects of the natural compound harmine2011

    • Author(s)
      Hara ES, Ono M, Kubota S, Sonoyama W, Hattori T, Takigawa M, Kuboki T
    • Organizer
      第24日本軟骨代謝学会
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2011-03-04

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Published: 2015-06-25  

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