2013 Fiscal Year Final Research Report
The study of the oxidative stress-induced neurodegeneration in CNS by using Tmem135 mutant mice
| Project/Area Number |
24792215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 酸化ストレス / 遺伝子変異マウス / Tmem135 |
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| Research Abstract |
The gene decoding projects in the word identified all genome sequence, and it was shown that there were still a lot of unknown genes.
In this study, I focused tmem135 (transmembrane135) that is one of unknown genes. I kept tmem135 mutant mice in high concentration oxygen to study the relationship between tmem135 and oxidative stress. In tmem135 mutant mice with high concentration oxygen, the oxidative stress marker was increased in comparison with normal mice. This suggested that tmem135 is the gene that associated with oxidative stress.
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