2014 Fiscal Year Final Research Report
New therapeutic target associated with epigenetic changes with epithelial-mesenchymal transition of oral cancer
| Project/Area Number |
24792255
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 口腔扁平上皮癌 / 上皮間葉移行 / DNAメチル化 |
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| Outline of Final Research Achievements |
We were able to induce the epithelial-mesenchymal transition and (EMT) by TGF-β stimulation in oral squamous cell carcinoma cells. It induces EMT by TGF-β stimulation, and the attenuation of E-cadherin, enhancement of N-cadherin could be confirmed. From exhaustive DNA methylation analysis, we identified GPR-37 as a gene that is induced methylation, and LOM2 and PALLD as genes that are induced hypomethylation by transfoemation change by EMT.
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| Free Research Field |
腫瘍分子生物学
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