2013 Fiscal Year Final Research Report
Peripheral nervous systems for development of new therapy in abnormal orofacial pain
| Project/Area Number |
24792258
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
HONDA Kuniya 日本大学, 歯学部, ポスト・ドクトラル・フェロー (20548945)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経因性疼痛 / 痛覚過敏 / TRP channel / グルタミン酸受容体 |
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| Research Abstract |
Peripheral tissue injury causes glutamate release from keratinocytes, resulting in hyperalgesia. We have reported that peripheral glutamate injection induces thermal hyperalgesia. However, it is still not understood the mechanisms underlying hyperalgesia following peripheral glutamate injection. To clarify the involvement of peripheral TRPA1, TRPV1 and PKC epsilon glutamate-induced hyperalgesia, we performed behavioral testing, immunohistochemistry and neuronal recording using glutamate injected rats. Present findings suggest that TRPA1 or TRPV1 activation through mGluR5 signaling via PKC epsilon is involved in facial thermal and mechanical hyperalgesia.
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Research Products
(12 results)
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[Journal Article] Nitric oxide signaling contributes to ectopic orofacial neuropathic pain2013
Author(s)
Sugiyama T, Shinoda M, Watase T, Honda K, Ito R, Kaji K, Urata K, Lee J, Ohara K, Takahashi O, Echizenya S, Iwata K
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Journal Title
J Dent Res
Volume: 92
Pages: 1113-1117
Peer Reviewed
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[Journal Article] Involvement of ERK Phosphorylation of Trigeminal Spinal Subnucleus Caudalis Neurons in Thermal Hypersensitivity in Rats with Infraorbital Nerve Injury2013
Author(s)
Suzuki I, Tsuboi Y, Shinoda M, Shibuta K, Honda K, Katagiri A, Kiyomoto M, Sessle BJ, Matsuura S, Ohara K, Urata K, Iwata K
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Journal Title
PLoS One
Volume: 8
Pages: e57278
Peer Reviewed
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[Journal Article] Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord2012
Author(s)
Liu MG, Matsuura S, Shinoda M, Honda K, Suzuki I, Shibuta K, Tamagawa T, Katagiri A, Kiyomoto M, Ohara K, Furukawa A, Urata K, Iwata K
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Journal Title
J Neuroinflammation
Volume: 27
Pages: 258
Peer Reviewed
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[Journal Article] Involvement of AMPA Receptor GluR2 and GluR3 Trafficking in Trigeminal Spinal Subnucleus Caudalis and C1/C2 Neurons in Acute-Facial Inflammatory Pain2012
Author(s)
Miyamoto M, Tsuboi Y, Honda K, Kobayashi M, Takamiya K, Huganir RL, Kondo M, Shinoda M, Sessle BJ, Katagiri A, Kita D, Suzuki I, Oi Y, Iwata K
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Journal Title
PLoS One
Volume: 7
Pages: e44055
Peer Reviewed
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