2014 Fiscal Year Final Research Report
Novel ameloblast marker Sox21 regulate the differentiation of dental epithelial cells?
| Project/Area Number |
24792294
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SAITO Kan 東北大学, 大学病院, 助教 (40380852)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | エナメル芽細胞 |
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| Outline of Final Research Achievements |
Sox21 which is a novel mature ameloblast marker was related to the differentiation to terminal ameloblasts from mature ameloblasts. Therefore, The cell polarity of a mature ameloblast disappears by absence of Sox21. For this reason, since a formation of an enamel rod is impeded, the abnormals in a crystal structure and hypomineralization of an enamel rod are triggered. Finally, The defect of Sox21 causes an amelogenesis imperfecta. Moreover, the expression of Sox21 in an ameloblast was regulated by Shh.
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| Free Research Field |
小児歯科
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