Analysis for mechanism of infective endocarditis caused by Streptococcus oralis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24792295
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KONISHI Ikuri 長崎大学, 医歯薬学総合研究科, 客員研究員 (00572380)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 歯学 / 口腔内常在細菌 / 感染性心内膜炎 / Streptococcus oralis / ゲノムシークエンス

Research Abstract

Infective endocarditis is characterized by formation of septic masses of platelets on the surfaces of heart valves and it most commonly caused by oral viridans streptococci. Although many factors may contribute to pathogenicity, onset of infective endocarditis still need to be further investigated. In this study, we attempt to determine whole genome sequence of Streptococcus oralis 308 isolated from infective endocarditis patient, and compare with invirulence strain of S. oralis to find the novel pathogenic genes. In present, we have generally finished determining the genome sequence, and intend genomic analysis.