2013 Fiscal Year Final Research Report
Effects of local blood flow improving agent on the periodontal tissue regeneration
| Project/Area Number |
24792324
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
MIKI Koji 大阪大学, 歯学部附属病院, 医員 (10598395)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 歯周再生医学 / 歯周組織再生 |
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| Research Abstract |
All of the mAchR family were expressed in MPDL22 at the mRNA level. Carpronium chrolide treatment enhanced the ALP activity and expression of ossification related genes, such as Runx2, Osterix, ALP, Collagen type I, Osteocalcin, Osteopontin, and Osteonectin, in the period of long term ossification culture. Furthermore, Carpronium chloride promoted calcified nodule formation of MPDL22 cells. In addition, it was confirmed that carpronium chrolide accelerated the tube formation of HUVECs on matrigel.These data suggest that application of carpronium chrolide on periodontal disease could stimulate periodontal tissue regeneration.
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