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2013 Fiscal Year Final Research Report

Effects of local blood flow improving agent on the periodontal tissue regeneration

Research Project

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Project/Area Number 24792324
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

MIKI Koji  大阪大学, 歯学部附属病院, 医員 (10598395)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords歯周再生医学 / 歯周組織再生
Research Abstract

All of the mAchR family were expressed in MPDL22 at the mRNA level. Carpronium chrolide treatment enhanced the ALP activity and expression of ossification related genes, such as Runx2, Osterix, ALP, Collagen type I, Osteocalcin, Osteopontin, and Osteonectin, in the period of long term ossification culture. Furthermore, Carpronium chloride promoted calcified nodule formation of MPDL22 cells. In addition, it was confirmed that carpronium chrolide accelerated the tube formation of HUVECs on matrigel.These data suggest that application of carpronium chrolide on periodontal disease could stimulate periodontal tissue regeneration.

  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] Carpronium chloride promotes the calcification of periodontal ligament cells2013

    • Author(s)
      Koji MIKI, Manabu YANAGITA, Kenta MORI, Mikiko KUBOTA, Motozo YAMASHITA Satoru YAMADA, Masahiro KITAMURA and Shinya MURAKAMI
    • Organizer
      International Association of Dental Research-Asia Pacific Region (IADR-APR)
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      20130821-23
  • [Presentation] 塩化カルプロニウムが歯根膜細胞および血管内皮細胞に及ぼす影響2013

    • Author(s)
      三木康史, 柳田 学, 伊山舜吉, 森 健太, 久保田実木子, 山下元三, 山田 聡, 北村正博, 村上伸也
    • Organizer
      第56回秋季日本歯周病学会学術大会
    • Place of Presentation
      前橋市 群馬
    • Year and Date
      2013-09-22

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Published: 2015-06-25   Modified: 2015-08-12  

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