Stydy of IGF-I for oral and maxillofacial smart aging

2015 Fiscal Year Final Research Report

• Project/Area Number: 24792347
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Kojima Ikuho 東北大学, 歯学研究科(研究院), 助教 (80447169)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: IGF-I / 顎骨

Outline of Final Research Achievements

We analyzed the longitudinal morphological changes in extraction sockets following sustained continuous subcutaneous infusion of insulin-like growth factor I (IGF-I). rats were subjected to right mandibular first molar extraction. Experimental rats received a continuous subcutaneous infusion of IGF-I by minipump. Control animals were treated with saline via the same method. All rats were then housed after stop of the infusion. Micro-CT scanning was performed immediately after tooth extraction and at regular intervals.
New bone formation was markedly higher in the IGF-I-treated group as compared with the control group. The loss in alveolar ridge height in the IGF-I group was significantly lower than that in the control group at each time point after extraction on the buccal side and at 2, 3, and 6 weeks on the lingual side. IGF-I treatment increases the volume of newly formed bone and reduces the loss in alveolar ridge height following tooth extraction.

Free Research Field

口腔診断学