2013 Fiscal Year Final Research Report
Kinetics of suppressor T cells in spontaneous tumor-bearing mice
| Project/Area Number |
24800033
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor immunology
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| Research Institution | Mie University |
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Principal Investigator |
SEO Naohiro 三重大学, 医学(系)研究科(研究院), 特任講師 (50283354)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 腫瘍所属リンパ節 / γδT細胞 / キラーT細胞 / 制御性T細胞 / 抑制免疫細胞 / 免疫抑制 |
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| Research Abstract |
IL-10- and IL-17-secreting gamma delta T cells expanded explosively in the medulla and subcapsular sinus of both draining and non-draining lymph nodes of subcutaneous 3-MCA-treated mice around two weeks before tumor formation. Abnormality of the innate IL-10+ IL-17+ gamma delta T cell expansion was demonstrated to be associated with the prevention of systemic circulation and the apoptosis induction of CD107a+ CD8+ mature CTLs and CD4+ Foxp3+ Treg cells in lymph nodes.
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Research Products
(8 results)
