2013 Fiscal Year Final Research Report
Redox regulation of mitochondrial functions: from molecular basis to physiological response
| Project/Area Number |
24870010
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
YOSHIDA Keisuke 東京工業大学, 資源化学研究所, 助教 (40632310)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | レドックス制御 / 植物生理学 / 植物生化学 / チオレドキシン / ミトコンドリア / シロイヌナズナ |
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| Research Abstract |
Redox state of plant mitochondria is known to fluctuate in response to environmental stimuli, but it is largely unknown how mitochondrial functions are regulated under such conditions. I screened mitochondrial target proteins of thioredoxin (Trx) that plays a pivotal role in redox regulation, and provided a list of redox-regulated protein candidates. Furthermore, using biochemical and physiological approaches, I examined molecular basis and physiological responses of redox regulation system in mitochondria. By these studies, I revealed that several key proteins in mitochondria is subjected to Trx-dependent redox regulation.
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