Elucidation of involvement of tumor blood vessel in tumor metastasis and regulation of tumor metastasis

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890007
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: MAISHI Nako 北海道大学, 歯学研究科(研究院), 特任助教 (00632423)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: 転移 / 腫瘍血管

Research Abstract

We analyzed the effects of tumor endothelial cells on tumor cells in tumor metastasis. In vivo analysis showed that highly metastatic tumor derived endothelial cells could promote tumor metastasis. We found some genes were upregulated in highly metastatic tumor-derived endothelial cells. When the genes were knocked down, tumor metastasis promoted by tumor endothelial cells described above was cancelled. Furthermore, the expression of the molecules in tumor blood vessels was confirmed in human clinical samples. These data suggested that the molecules which were upregulated in highly metastatic tumor-derived endothelial cells were involved in tumor metastasis.

Research Products

• [Journal Article] Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expression of Tumor and Normal Endothelial Cells (2014)
  • Author(s): Otsubo T., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K. and Hida K
  • Journal Title: Cancer sci Volume: 105(2014) Pages: 560-567
  • DOI: 10.1111/cas.12394
  • Peer Reviewed
• [Journal Article] Hypoxia - induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment (2013)
  • Author(s): Kondoh M., Ohga N., Akiyama K., Hida Y., Maishi N., Alam Mohammad Towfik, Inoue N., Shindoh M. and Hida K
  • Journal Title: PLoS ONE Volume: 8(11) Pages: e80349
  • DOI: 10.1371/journal.pone.0080349
  • Peer Reviewed
• [Journal Article] Heterogeneity of tumor endothelial cells (2013)
  • Author(s): Hida K., Ohga N., Akiyama K., Maishi N., Hida Y
  • Journal Title: Cancer Sci Volume: 104(11) Pages: 1391-1395
  • DOI: 10.1111/cas.12251
  • Peer Reviewed
• [Journal Article] Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis (2013)
  • Author(s): Osawa T., Ohga N., Akiyama K., Hida Y., Kitayama K., Kawamoto T., Yamamoto K. , Maishi N., Kondoh M., Onodera Y., Fujie M., Nonomura K., Shindoh M. and Hida K
  • Journal Title: Br J Cancer Volume: 109 Pages: 2237-2247
  • DOI: 10.1038/bjc.2013.535
  • Peer Reviewed
• [Journal Article] Application of POLARIC™fluorophores in an in vivo tumor model (2013)
  • Author(s): Maishi N., Kawamoto T., Ohga N., Yamada K., Akiyama K., Yamamoto K. , Osawa T., Hida Y. and Hida K
  • Journal Title: Oncol Rep Volume: 30(4) Pages: 1695-1700
  • DOI: 10.3892/or.2013.2620
  • Peer Reviewed
• [Journal Article] The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma (2013)
  • Author(s): Akiyama K., Ohga N., Maishi N., Hida Y., Kitayama K., Kawamoto T., Osawa T., Suzuki Y., Shinohara N., Nonomura K., Shindoh M., Hida K
  • Journal Title: Pathol Int Volume: 63(1) Pages: 37-44
  • DOI: 10.1111/pin.12031
  • Peer Reviewed
• [Journal Article] Tumor endothelial cells acquire drug resistance in a tumor microenvironment (2013)
  • Author(s): Hida K., Akiyama K., Ohga N., Maishi N., Hida Y
  • Journal Title: J Biochem Volume: 153(3) Pages: 243-249
  • DOI: 10.1093/jb/mvs152
  • Peer Reviewed
• [Presentation] 血管内皮細胞によるがん転移促進 (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 20131003-05
• [Presentation] がん転移における腫瘍血管内皮細胞の役割 (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第21回日本血管生物医学会学術集会
  • Place of Presentation: 千里阪急ホテル(大阪府豊中市)
  • Year and Date: 20130926-28
• [Presentation] がん転移における腫瘍血管内皮細胞の役割 (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第22回日本がん転移学会学術集会・総会
  • Place of Presentation: ホテルブエナビスタ(松本市)
  • Year and Date: 20130711-12
• [Presentation] 腫瘍血管内皮細胞のがん転移への関与 (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌,さっぽろ芸文館(札幌市)
  • Year and Date: 20130606-08
• [Presentation] 転移能の異なる腫瘍由来の血管内皮細胞の特性解析 (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第67回日本口腔科学会学術集会
  • Place of Presentation: 栃木総合文化センター(宇都宮市)
  • Year and Date: 20130522-24
• [Presentation] 腫瘍血管内皮細胞のがん転移への関わり (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第67回日本口腔科学会学術集会
  • Place of Presentation: 栃木総合文化センター(宇都宮市)
  • Year and Date: 20130522-24
• [Presentation] Tumor endothelial cells promote metastasis (2013)
  • Author(s): Maishi N., et al
  • Organizer: The 18th Japan-Korea Cancer Research Workshop
  • Place of Presentation: 岐阜都ホテル(岐阜市)
  • Year and Date: 2013-11-30
• [Presentation] がん転移における腫瘍血管内皮細胞の役割 (2013)
  • Author(s): 間石奈湖など
  • Organizer: 第46回北海道病理談話会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2013-10-12
• [Presentation] The role of tumor endothelial cells in tumor metastasis (2012)
  • Author(s): 間石奈湖など
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(札幌市)
  • Year and Date: 2012-09-21
• [Presentation] 腫瘍血管内皮細胞のがん転移への関わり (2012)
  • Author(s): 間石奈湖など
  • Organizer: 第92回北海道医学大会(第106回北海道癌談話会例会腫瘍系分科会)
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-09-08
• [Remarks]
  • URL: http://www.igm.hokudai.ac.jp/vascular-biology/