2013 Fiscal Year Final Research Report
New function of LPA3 receptor that regulates vagal afferent nerves activation
| Project/Area Number |
24890014
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
KANO KUNIYUKI 東北大学, 薬学研究科(研究院), 助教 (50636404)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | リゾホスファチジン酸 / 虚血性心疾患 |
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| Research Abstract |
In this study, we assessed the functional effects of LPA3 signal-induced vagal excitation and quantifying LPA and other lysophospholipids level in myocardial infarction.
We found that injection of LPA3 agonist named T13, which is 2-acyl LPA analog, significantly decreased infact area in acute ischemic injury model. We analyzed clinical specimen (plasma) from acute coronary syndrome (ACS) patients by LC-MS/MS, and found unsaturated LPA, which show potent agonist activity for LPA3, were selectively elevated in ACS. In addition, other unsaturated lysophospholipids (LPC, LPE, LPG, LPI, LysoPS) were also increased. These results suggest that unsaturated LPA are produced by increased substrates of autotaxin in myocardial infarction.
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[Journal Article] Overexpression of autotaxin, a lysophosphatidic acid - producing enzyme, enhances cardia bifida induced by hypo - sphingosine - 1 - phosphate signaling in zebrafish embryo2014
Author(s)
Nakanaga, Keita; Hama, Kotaro; Kano, Kuniyuki; Sato, Takanao; Yukiura, Hiroshi; Inoue, Asuka; Saigusa, Daisuke; Tokuyama, Hidetoshi; Tomioka, Yoshihisa; Nishina, Hiroshi; Kawahara, Atsuo; Aoki, Junken
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Journal Title
The Journal of Biochemistry
Volume: vol.155
Pages: 235-241
DOI
Peer Reviewed
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