Analysis of miRNA in the liver cancer stem cell: For cancer chemoprevention and metastasis suppression

2013 Fiscal Year Final Research Report

• Project/Area Number: 24890081
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: SUETSUGU Atushi 岐阜大学, 医学部附属病院, 助教 (30340079)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Keywords: 肝癌 / 癌幹細胞 / miRNA

Research Abstract

Cancer cells form microenvironment in primary tumor and metastatic formation. The cancer-associated cells play an important role. Cancer-associated fibroblast cells and tumor-associated macrophages are important at the time of the liver metastasis formation. Cancer cells shed exosomes and transfer exosomal molecules to fibroblast cells during tumor progression. We confirmed that cancer cells release exosomes into the circulation of mice with liver metastasis. We collected blood from mice and detected exosomes. Imaging of exosomes can contribute to understanding the role of intercellular communication in tumor progression. Tumor-drived exosomes have been viewd as a mediater to condition tissues and prepare niches for metastasis.

Research Products

• [Journal Article] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis : chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids (2014)
  • Author(s): Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H
  • Journal Title: Mol Nutr Food Res. Volume: 58(1) Pages: 124-35
• [Journal Article] Free fatty acid as a marker of energy malnutrition in liver cirrhosis (2014)
  • Author(s): Hanai T, Shiraki M, Nishimura K, Imai K, Suetsugu A, Takai K, Shimizu M, Naiki T, Moriwaki H
  • Journal Title: Hepatol Res. Volume: 44(2) Pages: 218-28
• [Journal Article] Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level (2013)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM
  • Journal Title: J Cell Biochem. Volume: 114(2) Pages: 428-34
• [Journal Article] Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude mouse models (2013)
  • Author(s): Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM
  • Journal Title: Adv Drug Deliv Rev. Volume: 65(3) Pages: 383-90
• [Journal Article] Subcellular real-time imaging of the efficacy of temozolomide on cancer cells in the brain of live mice (2013)
  • Author(s): Momiyama M, Suetsugu A, Chishima T, Bouvet M, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(1) Pages: 103-6
• [Journal Article] Enhanced resection of orthotopic red-fluorescent-protein-expressing human glioma by fluorescence-guided surgery in nude mice (2013)
  • Author(s): Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Yano S, Bouvet M, Chishima T, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(1) Pages: 107-11
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer (2013)
  • Author(s): Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O
  • Journal Title: J Clin Invest. Volume: 123(2) Pages: 834-43
• [Journal Article] Dynamic subcellular imaging of cancer cell mitosis in the brain of live mice (2013)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Chishima T, Bouvet M, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(4) Pages: 1367-71
• [Journal Article] In vivo fluorescence imaging reveals the promotion of mammary tumorigenesis by mesenchymal stromal cells (2013)
  • Author(s): Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM
  • Journal Title: PLoS One Volume: 8(7) Pages: e69658
• [Journal Article] Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM
  • Journal Title: Cell Cycle Volume: 12(17) Pages: 2774-80
• [Journal Article] Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling (2013)
  • Author(s): He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M
  • Journal Title: Cell Volume: 155(2) Pages: 384-96
• [Journal Article] Imaging nuclear - cytoplasm dynamics of cancer cells in the intravascular niche of live mice (2013)
  • Author(s): Suetsugu A, Jiang P, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 33(10) Pages: 4229-36
• [Journal Article] Development of a clinically-precise mouse model of rectal cancer (2013)
  • Author(s): Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM
  • Journal Title: PLoS One Volume: 8(11) Pages: e79453
• [Journal Article] Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice (2012)
  • Author(s): Zhao M, Suetsugu A, Ma H, Zhang L, Liu F, Zhang Y, Tran B, Hoffman RM
  • Journal Title: Cell Cycle Volume: 1 Pages: 187-93
• [Journal Article] The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments (2012)
  • Author(s): Suetsugu A, Hassanein MK, Reynoso J, Osawa Y, Nagaki M, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 1 Pages: 31-8
• [Journal Article] Imageable Metastasis Occuring in Transgenic GFP Mice Orthotopically Implanted with Human-Patient Primary Pancreatic Cancer Specimens (2012)
  • Author(s): Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 4 Pages: 1175-80
• [Journal Article] Major liver resection stimulates atromal recruitment and metastasis compared with repeated minor resection (2012)
  • Author(s): Momiyama M, Kumamoto T, Suetsugu A, Kishimoto H, Chishima T, Tanaka K, Akiyama H, Ichikawa Y, Bouvet M, Endo I, Hoffman RM
  • Journal Title: J Surg Res. Volume: 178(1) Pages: 280-7
• [Journal Article] Multi-color pallet of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens (2012)
  • Author(s): Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Journal Title: J Cell Biochem. Volume: 7 Pages: 2290-5
• [Journal Article] Inhibition of metastasis of circulating human prostate cancer cells in the chick embryo by an extracellular matrix produced by foreskin fibroblasts in culture (2012)
  • Author(s): Menen R, Pinney E, Hassanein MK, Kolostova K, Bobek V, Suetsugu A, Zhang N, Bouvet M, Naughton GK, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 5 Pages: 1573-7
• [Journal Article] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice (2012)
  • Author(s): Zhang Y, Tome Y, Suetsugu A, Zhang L, Zhang N, Hoffman RM, Zhao M
  • Journal Title: Anticancer Res. Volume: 7 Pages: 2501-8
• [Journal Article] Real-time imaging of apoptosis induction of human breast cancer cells by the traditional Chinese medicinal herb tubeimu (2012)
  • Author(s): Hu M, Zhao M, An C, Yang M, Li Q, Zhang Y, Suetsugu A, Tome Y, Yano S, Fu Y, Hoffman RM, Hu K
  • Journal Title: Anticancer Res. Volume: 7 Pages: 2509-14
• [Journal Article] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer (2012)
  • Author(s): Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Moossa AR, Hoffman RM, Bouvet M
  • Journal Title: In Vivo. Volume: 26(4) Pages: 565-9
• [Journal Article] Non-invasive Fluorescent-protein Imaging of Orthotopic Pancreatic-cancer-patient Tumorgraft Progression in Nude Mice (2012)
  • Author(s): Suetsugu A, Katz M, Fleming J, Truty M, Thomas R, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 8 Pages: 3063-7
• [Journal Article] Fluorescent proteins enhance UVC PDT of cancer cells (2012)
  • Author(s): Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Bulgakova NN, Endo I, Hoffman RM
  • Journal Title: Anticancer Res. Volume: 10 Pages: 4327-30. 25
• [Presentation] C型慢性肝炎IFN治療SVR後の発癌症例の検討末次淳 (2013)
  • Author(s): 内木隆文、森脇久隆
  • Organizer: 第40回日本肝臓学会西部会 シンポジウム
  • Year and Date: 20131206-07
• [Presentation] Salmonella typhimurium A1-R targets chemoresistant stem-like human pancreatic cancer cells (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Hassanein MK, Suetsugu A, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM
  • Organizer: American Society of Clinical Oncology (ASCO)
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 20130531-0604
• [Presentation] Salmonella typhimurium A1-R effectively targets human-patient pancreatic tumorgrafts in nude mice (2013)
  • Author(s): Zhao M, Katz MH, Fleming J, Suetsugu A, Zhang Y, Ali Maawy, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM, Hiroshima Y
  • Organizer: American Society of Clinical Oncology (ASCO)
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 20130531-0604
• [Presentation] CHARACTERIZATION AND IMAGING OF CD133+ LIVER CANCER STEM CELLS (2013)
  • Author(s): Suetsugu A, Y. Osawa, H. Aoki, T. Kunisada, H. Tsurumi,R.M. Hoffman, H. Moriwaki
  • Organizer: European Association for the Study of the Liver (EASL)
  • Place of Presentation: Amsterdam (The Netherlands)
  • Year and Date: 20130424-28
• [Presentation] ACID SPHINGOMYELINASE INHIBITS GROWTH OF METASTATIC LIVER TUMOR (2013)
  • Author(s): Y. Osawa, A. Suetsugu, H. Moriwaki, O. Kozawa
  • Organizer: European Association for the Study of the Liver (EASL)
  • Place of Presentation: Amsterdam (The Netherlands)
  • Year and Date: 20130424-28
• [Presentation] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Mohamed Hassanein, Suetsugu A, Chishima T, Kuniya Tanaka, Bouvet M, Endo I, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
  • Year and Date: 20130406-10
• [Presentation] Cancer cell location in tumor determines cell cycle position and dormancy (2013)
  • Author(s): Yano S, Tome Y, Michelle Digman, Momiyama M, Suetsugu A, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
  • Year and Date: 20130406-10
• [Presentation] Imaging of methioninase-induced S/G_2-phase-trapping for subsequent effective chemotherapy (2013)
  • Author(s): Yano S, Tome Y, Michelle Digman, Momiyama M, Suetsugu A, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
  • Year and Date: 20130406-10
• [Presentation] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts (2013)
  • Author(s): Zhao M, Katz MH, Fleming J, Suetsugu A, Zhang Y, Ali Maawy, Chishima T, Kuniya Tanaka, Bouvet M, Hiroshima Y, Endo I, Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
  • Year and Date: 20130406-10
• [Presentation] Imaging exosome transfer from colon cancer cells to stroma at liver metastatic sites in nude mouse (2013)
  • Author(s): Suetsugu A, Honma K, Saji S, Moriwaki H, Ochiya T, Hoffman RM. Hoffman RM
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: Washington DC
  • Year and Date: 20130406-10
• [Presentation] HIV感染治療開始後に伴うB型肝炎の免疫再構築症候群の検討末次淳 (2013)
  • Author(s): 宮崎恒起、華井竜徳、今井健二、白木亮、高井光治、清水雅仁、内木隆文、鶴見寿、森脇久隆
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2013-10-10
• [Presentation] 当院におけるC型慢性肝炎に対する3剤併用療法の初期治療効果と副作用の検討末次淳 (2013)
  • Author(s): 宮崎恒起、華井竜徳、今井健二、白木亮、高井光治、大澤陽介、清水雅仁、内木隆文、森脇久隆
  • Organizer: JDDW
  • Place of Presentation: 東京
  • Year and Date: 2013-10-09
• [Presentation] Comparison of Salmonella typhimurium A1-R and chemotherapy of human-patient pancreatic tumorgrafts (2013)
  • Author(s): Hiroshima Y, Zhao M, Zhang Y, Ali Maawy, Hassanein MK, Suetsugu A, Chishima T, Kuniya Tanaka, Micheal Bouvet, Endo I, Hoffman RM
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-05
• [Presentation] Cell cycle position and chemoresponse depends on location in tumor (2013)
  • Author(s): Tome Y, Michelle A. Digman, Momiyama M, Suetsugu A, Enrico Gratton, Yano S, Hoffman RM
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-03
• [Presentation] L-tryptophan-mediated enhancement of susceptibility to NAFLD is dependent on the mTOR (2012)
  • Author(s): Yosuke Osawa, Yoichi Yasuda, Suetsugu A, Moriwaki H, Osamu Kozawa
  • Organizer: Asian pacific Digestive Week 2012
  • Place of Presentation: Bangkok,Thailand
  • Year and Date: 20121205-08
• [Presentation] Potential use of CD133-positive bone marrow cells in the treatment of liver fibrosis (2012)
  • Author(s): Suetsugu A, Yosuke Osawa, Hitomi Aoki, Takahiro Kunisada, Ogata H, Hisashi Tsurumi, Hoffman RM, Moriwaki H
  • Organizer: Asian pacific Digestive Week 2012
  • Place of Presentation: Bangkok,Thailand
  • Year and Date: 20121205-08
• [Presentation] RFP-expressing glioma successfully resected in othotopic mouse models using fluorescence-guided surgery (2012)
  • Author(s): Momiyama M, Suetsugu A, Kishimoto H, Chishima T, Bouvet M, Endo I
  • Organizer: World Molecular imaging congress (WMIC) 2012
  • Place of Presentation: Dublin
  • Year and Date: 20120905-08
• [Presentation] Multi-color imaging model of the tumor environment (2012)
  • Author(s): Suetsugu A, Katz MH, Fleming J, Hassanein MK, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢
  • Year and Date: 20120712-13
• [Presentation] Salmonella typhimurim can eradicate human glioma in a nude mouse orthotopic model (2012)
  • Author(s): Momiyama M, Zhao M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Micheal Bouvet, Chishima T, Endo I, Hoffman RM
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 金沢
  • Year and Date: 20120712-13
• [Presentation] Effect of major liver resection on colon cancer metastasis in the lung and liver (2012)
  • Author(s): Hoffman RM, Momiyama M, Suetsugu A, Kishimoto H, Chishima T, Bouvet M, Endo I
  • Organizer: American Society of Clinical Oncology (ASCO) 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120601-05
• [Presentation] Determining the metastatic potential of circulating tumor cells (2012)
  • Author(s): Menen RS, Emmett Pinney, Katarina Kolostova, Vladimir Bobek, Suetsugu A, Nan Zhang, Hoffman RM
  • Organizer: American Society of Clinical Oncology (ASCO) 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120601-05
• [Presentation] Determination of the optimal route of administration of Salmonella typhimurium A1-R to target breast cancer in nude mice (2012)
  • Author(s): Zhang Y, Suetsugu A, Nan Zhang, Lei Zhang, Hoffman RM, Zhao M
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] In vivo tracking of cancer-cell-derived exosomes (2012)
  • Author(s): Honma K, Suetsugu A, Ochiya T, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Multicolor imageable orthotopic tumorgraft models of human patient pancreatic cancer (2012)
  • Author(s): Suetsugu A, Katz MH, Fleming J, Hassanein MK, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Imaging stromal recruitment during liver metastasis formation in the GFP-MUP-uPA mouse (2012)
  • Author(s): Suetsugu A, Ogata H, Moriwaki H, Saji S, Karin M, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer (2012)
  • Author(s): Menen RS, Hassanein MK, Momiyama M, Suetsugu A, Abdool R. Moossa, Bouvet M, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Imaging sub-cellular dynamics of proliferating intra- and extra-vascular cancer cells (2012)
  • Author(s): Suetsugu A, Michelle Digman, Jose A. Aguilar, Ping Jiang, Mohamed Hassanein, Moriwaki H, Bouvet M, Saji S, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Imaging cell cycle progression in gastric cancer lymph node metastasis indicates large fraction of proliferating cancer cells (2012)
  • Author(s): Suetsugu A, Mohamed Hassanein, Moriwaki H, Yano S, Toshiyoshi Fujiwara, Bouvet M, Saji S, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Color-coded imaging of the pre-metastatic niche in the lung and liver indicates the involvement of cancer-associated fibroblasts (2012)
  • Author(s): Suetsugu A, Momiyama M, Yosuke Osawa, Moriwaki H, Bouvet M, Saji S, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Raster-image-correlation spectroscopy of paxillin-GFP-expressing breast cancer cell in vitro and in vivo (2012)
  • Author(s): Suetsugu A, Michelle Digman, Federica Sabatini, Moriwaki H, Saji S, Enrico Gratton, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Imaging of the interaction of pancreatic cancer and stellate cells during liver metastasis (2012)
  • Author(s): Suetsugu A, Cynthia Snyder, Moriwaki H, Saji S, Bouvet M, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Real-time imaging of inter-cellular communication via exosomes (2012)
  • Author(s): Honma K, Suetsugu A, Ochiya T, Hoffman RM
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: Chicago
  • Year and Date: 20120331-0404
• [Presentation] Fluorescence lifetime imaging microcopy of extravasating cancer cells in the mouse microenvironment (2012)
  • Author(s): Michelle A. Digman, Suetsugu A, Federica Sabatini, Hoffman RM, Enrico Gratton
  • Organizer: 56th Annual Meeting of the Biophysical Society
  • Place of Presentation: San Diego, California
  • Year and Date: 20120225-29
• [Presentation] Highly-effective resection of orthotopic human glioma by fluorescence-guided surgry in nude mice (2012)
  • Author(s): Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Micheal Bouvet, Chishima T, Endo I, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] Treatment of brain tumors in nude mice with intra-cranial UV irradiation (2012)
  • Author(s): Satoshi Hasegawa, Momiyama M, Hiroshima Y, Suetsugu A, Tome Y, Mii S, Syuya Yano, Chishima T, Micheal Bouvet, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] Role of stellate cells during liver metastasis of pancreatic cancer in nude mice Cynthia Snyder (2012)
  • Author(s): Suetsugu A, Moriwaki H, Saji S, Micheal Bouvet, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
• [Presentation] Paxillin-expressing breast cancer imaged by raster-image-correlation spectroscopy of GFP in vivo and in vitro (2012)
  • Author(s): Suetsugu A, Michelle Digman, Federica Sabatini, Moriwaki H, Saji S, Micheal Bouvet, Enrico Grattion, Hoffman RM
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Use of fluorescent protein labeling of storoma to image orthotopic pancreatic patient tumors in nude mice (2012)
  • Author(s): Hoffman RM, Suetsugu A, Matthew H Katz, Fleming J, Mark Truty, Ryan Thomas, Hassanein MK, Moriwaki H, Micheal Bouvet, Saji S
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Trafficking of exosomes imaged in vivo with GFP (2012)
  • Author(s): Ochiya T, Kimi Honma, Suetsugu A
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] Making patient tumors glow in nude mice by coloring the stroma with fluorescent proteins (2012)
  • Author(s): Suetsugu A, Katz MH, Fleming J, Mark Truty, Saji S, Moriwaki H, Bouvet M, Hoffman RM
  • Organizer: 第10回日本臨床腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-07-27