2013 Fiscal Year Final Research Report

global genetic analysis of inflammatory bowel disease associated with primary immunodeficiency

Research Project

Project/Area Number	24890095
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pediatrics
Research Institution	Kyoto University
Principal Investigator	KAWAI Tomoki 京都大学, 医学(系)研究科(研究院), 助教 (20631568)
Project Period (FY)	2012-08-31 – 2014-03-31
Keywords	下部消化管学 / 免疫学
Research Abstract	A role for mucosal associated invariant T (MAIT) cells has recently been reported in several autoimmune diseases, but contribution to inflammatory bowel disease (IBD) has yet to be described. Here, we analyzed the MAIT cells in the peripheral blood of 88 ulcerative colitis patients and 68 Crohn's disease patients, and intestinal mucosae of 5 ulcerative colitis disease patients and 10 Crohn's disease patients. MAIT cells are significantly reduced both in the peripheral blood and the intestinal mucosa of IBD patients. Furthermore, the proportion of MAIT cells producing IL-17 was higher in Crohn's disease patients compared to controls. These results suggest the association of MAIT cells with pathophysiology of IBD.

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