2013 Fiscal Year Final Research Report
Development of novel periodontal tissue regenerative therapy by small molecule ligands induced TrkB transactivation
Project/Area Number |
24890142
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Periodontal dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2012-08-31 – 2014-03-31
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Keywords | 再生医療 |
Research Abstract |
It is previously reported that Brain-derived neurotrophic factor (BDNF) stimulates cementoblast differentiation via its high affinity receptor, TrkB. In this present study, an applicant have discovered that small molecule BDNF mimetic, LM22A-4, also activates TrkB signaling cascade in cementoblast. This result has been published in International Immunopharmacology.
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Research Products
(3 results)
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[Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/AKt signaling cascade2014
Author(s)
Mikihito Kajiya, Kei Takeshita, Mizuho Kittaka, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, and Hidemi Kurihara
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Journal Title
International Immunopharmacology
Volume: 19
Pages: 245-252
Peer Reviewed
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