2013 Fiscal Year Final Research Report
The role and new therapeutic strategy of autophagy in pancreatic cancer.
Project/Area Number |
24890172
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
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Project Period (FY) |
2012-08-31 – 2014-03-31
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Keywords | オートファジー / 膵癌 / 5-FU / ゲムシタビン / クロロキン |
Research Abstract |
Autophagy is a regulated process of degradation and recycling of cellular constituents. We showed that autophagy is up-regulated in human pancreatic cancer and contributes to pancreatic cancer cell growth, and has a cytoprotective effect against anti-cancer drug in pancreatic cancer cells. Combination therapy of these anticancer drugs and chloroquine should be investigated.
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[Journal Article] Distal pancreatectomy using a no-touch isolation technique2012
Author(s)
Hirota M, Hashimoto D, Ishiko T, Satoh N, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H
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Journal Title
Scand J Surg
Volume: 101(3)
Pages: 156-9
URL
Peer Reviewed
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