2013 Fiscal Year Final Research Report
Investigation of the function of nucleostemin in oral squamous cell carcinoma and develop the new therapeutic approoach
Project/Area Number |
24890173
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Kumamoto University |
Principal Investigator |
YOSHIDA Ryoji 熊本大学, 医学部附属病院, 医員 (10632458)
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Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Masanori 熊本大学, 大学院生命科学研究部 歯科口腔外科学分野, 教授 (90117127)
ITO Takaaki 熊本大学, 大学院生命科学研究部 機能病理学分野, 教授 (70168392)
NAKAYAMA Hideki 熊本大学, 大学院生命科学研究部 歯科口腔外科学分野, 講師 (70381001)
|
Project Period (FY) |
2012-08-31 – 2014-03-31
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Keywords | 口腔癌 / 癌幹細胞 |
Research Abstract |
The purpose of this study was to explore the impact of Nucleostemin (NS) on malignancy,its clinical significance in oral squamous cell carcinoma (OSCC) patients and develop new therapeutic approach. We investigated the effects of NS on the proliferation and invasion of OSCC using NS-overexpressing or -knockdown OSCC cells. An immunohistochemical analysis of NS was performed in OSCC patients. The expression status of NS significantly correlated to the malignant phenotypes of OSCC cells. The alterations of these malignant phenotypes were associated with the activation of STAT3 signaling and its downstream targets. An immunohistochemical analysis demonstrated that a high NS tumor expression level significantly correlated with an advanced T-stage and nodal status. Furthermore, a Cox regression analysis revealed that the NS status was a significant progression factor for OSCC patients.Our results suggest that targeting NS may provide a promising treatment for highly malignant OSCC.
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[Presentation] Overexpression of Nucleostemin contributes to malignant phenotype and poor prognosis in oral squamous cell carcinoma2013
Author(s)
Yoshida R, Nakayama H, Nagata M, Hirosue A, Kawahara K, Nakagawa Y, Hiraki A, Ito T, Shinohara M
Organizer
21st International conference on oral and maxillofacial surgery
Place of Presentation
Palau de Congressos, Barcelona, Spain
Year and Date
2013-10-23
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[Presentation] The possible impacts of nucleostemin on cancer stem cells in oral squamous cell carcinoma2012
Author(s)
Ryoji Yoshida, Hideki Nakayama, Masashi Nagata, Akiyuki Hirosue, Takuya Tanaka, Kenta Kawahara, Yoshihiro Nakagawa, Yoshihiro Yoshitake, Kazutoshi Ota, Akimitsu Hiraki, Takaaki Ito, Masanori Shinohara
Organizer
第71回日本癌学会学術総会
Place of Presentation
ロイトン札幌、北海道
Year and Date
2012-09-20
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