2013 Fiscal Year Final Research Report
CEACAM1 isoform balance affects morphogenesis and stromal reaction of colorectal cancer
| Project/Area Number |
24890209
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IEDA Junji 和歌山県立医科大学, 医学部, 学内助教 (50637907)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Keywords | 大腸癌 / 間質 / 悪性度 |
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| Research Abstract |
The purpose of this study is to clarify the mechanism of metastasis and invasion of colorectal cancer. We studied about the relationship between CEACAM1 isoform balance and stroma of colorectal cancer.
The colorectal cancer with CEACAM1-long dominant expression was associated with b2-integrin expression in stroma of cancer (p=0.03). The patients with b2-integrin expression were associated with lymph node metastasis and hematogenous metastasis (p=0.0004, p=0.0001). CEACAM1-long dominant expression may enhance cancer invasion and metastasis through an interaction with b2-integrin.
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