Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development

2017 Fiscal Year Final Research Report

• Project/Area Number: 25221302
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIJO Hidenori 東京大学, 大学院薬学系研究科(薬学部), 教授 (00242206)
• Co-Investigator(Renkei-kenkyūsha): NAGURO Isao 東京大学, 大学院薬学系研究科, 准教授 (80401222) ; FUJISAWA Takao 東京大学, 大学院薬学系研究科, 助教 (50636644) ; SEKINE Shiori 東京大学, 大学院薬学系研究科, 助教 (70612654)
• Project Period (FY): 2013-05-31 – 2018-03-31
• Keywords: ASK1 / ASKファミリー / 酸化ストレス / 浸透圧ストレス / 小胞体ストレス / ミトコンドリアストレス

Outline of Final Research Achievements

In this project, we focused on 4 themes, (1) Oxidative stress response regulated with ASK family complexes, (2) Bidirectional osmotic stress response regulated by ASK3, (3) ER stress response and Zn homeostasis regulated by SOD1/Derlin-1 interaction, (4) Mitochondria stress response through cleavage of PGAM5. All of themes are originated from our previous findings, and we have further promoted the knowledge of these stress response in molecular and in vivo level, clarifying novel molecular mechanisms and providing foundation of drug discovery.

Free Research Field

生化学、分子生物学