2016 Fiscal Year Final Research Report
Development of next-gen DDS carrier by utilizing virus envelope-derived functional domains
| Project/Area Number |
25242043
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University (2015-2016)
Nagoya University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | DDS / ウイルス / ナノキャリア |
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| Outline of Final Research Achievements |
Through the analysis of hepatitis B virus envelope protein, we have identified the following novel functional domains: active targeting domain, stealth domain, and cell invasion domain. By displaying these domains as synthetic peptide, the artificial and conventional DDS carriers could function as next-gen DDS carrier that functions like hepatitis B virus. Furthermore, in other viruses, we have identified similar functional domains in their envelope proteins. These results strongly suggested that various next-gen DDS carriers could be generated by this strategy.
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| Free Research Field |
分子細胞生物学
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