ＯｐｅｎＰＥＴによる「その場」がん治療イメージング手法の研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 25242052
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: 山谷 泰賀 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (40392245)
• Co-Investigator(Kenkyū-buntansha): 菅 幹生 千葉大学, 学内共同利用施設等, 准教授 (00294281) ; 羽石 秀昭 千葉大学, 学内共同利用施設等, 教授 (20228521) ; 志田原 美保 (古本美保) 東北大学, 医学(系)研究科(研究院), 講師 (20443070) ; 河合 秀幸 千葉大学, 理学(系)研究科(研究院), 准教授 (60214590) ; 高橋 浩之 東京大学, 工学(系)研究科(研究院), 教授 (70216753)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 画像診断システム / PET / 画像再構成 / 放射線がん診断 / 核医学

Outline of Annual Research Achievements

本研究は、世界初の開放型PET「OpenPET」を発明し、従来技術では不可能であった、PETでみながらの放射線治療やPETでみながらの外科手術の実現を目指した。初期アイディアの二重リング方式（2008年発表）は、より治療イメージングに最適化された単一リング型の第二世代OpenPETへ進化した（2011年発表）。そこで本研究では、第二世代OpenPETの実現や発展に不可欠な革新的要素技術を集約的に研究し、中型試作機を開発して実証を行った。最大の特徴は、検出器ユニットを独立して軸方向にスライドするようにして、通常のPETとOpenPETを自在に切り替えられるようにする点である。リング直径は25cm前後にして、ウサギ等の比較的大きな動物を測定できるようにした。並行して、第二世代OpenPETに特化した画像再構成手法の開発や、粒子線照射場での安定性を高めるために必要な高性能放射線計測回路の開発や放射化影響の対策など、可変型第二世代OpenPETの要素技術開発を行った。また、OpenPETの応用を広げる技術として、腫瘍トラッキングシステムの開発や粒子線治療での「その場」がん性状計測法の研究も行った。具体的な研究実績は以下のとおりである。
（ア）可変型第二世代OpenPETの要素技術開発：（ア-1）画像再構成手法開発：中型試作機へ実装。ファントム実験等で性能評価。（ア-2）高性能放射線計測回路開発：耐放射線性能を向上させたCMOSのASICの実装。（ア-3）放射化影響対策：照射中の放射化量の測定。
（イ）腫瘍トラッキングシステムの開発：腫瘍トラッキングシステムのパラメータ最適化と中型試作機への実装。
（ウ）粒子線治療での「その場」がん性状計測法の研究：開発する中型試作機を用いた動物実験。
（エ）中型試作機開発・実証試験[放医研]：ガントリ開発、試作機組み立て、評価実験。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Development of a small single-ring OpenPET prototype with a novel transformable architecture (2016)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Naoko Inadama, Fumihiko Nishikido, Yasunori Nakajima, Hidekatsu Wakizaka, Tetsuya Shinaji, Munetaka Nitta, Shoko Kinouchi, Mikio Suga, Hideaki Haneishi, Taku Inaniwa, Taiga Yamaya,
  • Journal Title: Phys. Med. Biol. Volume: 61 Pages: 1795-1809
  • DOI: 10.1088/0031-9155/61/4/1795
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Washout rate in rat brain irradiated by a 11C beam after acetazolamide loading using a small single-ring OpenPET prototype (2016)
  • Author(s): Yoshiyuki Hirano, Hiroyuki Takuwa, Eiji Yoshida, Fumihiko Nishikido, Yasunori Nakajima, Hidekatsu Wakizaka, Taiga Yamaya
  • Journal Title: Phys. Med. Biol. Volume: 61 Pages: 1875-1887
  • DOI: 10.1088/0031-9155/61/5/1875
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 15O beam productoin for in-beam PET imaging (2015)
  • Author(s): Akram Mohammadi, Chie Toramatsu, Eiji Yoshida, Hideaki Tashima, Fumihiko Nishikido, Taku Inaniwa, Atsushi Kitagawa, Taiga Yamaya
  • Organizer: The 2nd International Symposium of Gunma University Medical Innovation (GUMI2015)
  • Place of Presentation: Gunma University
  • Year and Date: 2015-12-08 – 2015-12-08
  • Int'l Joint Research / Invited
• [Presentation] PET Innovations for High Resolution Diagnosis and Treatment Imaging (2015)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Fumihiko Nishikido, Hideaki Tashima
  • Organizer: World Engineering Conference and Convention (WECC2015)
  • Place of Presentation: Kyoto
  • Year and Date: 2015-12-01 – 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] Patient Data-Based Monte Carlo Simulation of in-Beam Single-Ring OpenPET Imaging (2015)
  • Author(s): H. Tashima, C. Kurz, E. Yoshida, J. Debus, K. Parodi, T. Yamaya
  • Organizer: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Town and Country Resort and Convention Center, San Diego
  • Year and Date: 2015-11-06 – 2015-11-06
  • Int'l Joint Research
• [Presentation] Total Variation Reconstruction of 12C Beams Measured with the Whole Body Dual Ring OpenPET Scanner (2015)
  • Author(s): J. Cabello, H. Tashima, E. Yoshida, S. I. Ziegler, T. Yamaya
  • Organizer: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Town and Country Resort and Convention Center, San Diego
  • Year and Date: 2015-11-06 – 2015-11-06
  • Int'l Joint Research
• [Presentation] Development of a Whole-Body Single-Ring OpenPET for in-Beam Particle Therapy Imaging (2015)
  • Author(s): E. Yoshida, H. Tashima, F. Nishikido, M. Nitta, K. Shimizu, T. Inaniwa, T. Yamaya
  • Organizer: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Town and Country Resort and Convention Center, San Diego
  • Year and Date: 2015-11-05 – 2015-11-05
  • Int'l Joint Research
• [Presentation] In-Beam OpenPET Measurement of Washout Rate in Rabbit Brain and Thigh Using 10C, 11C and 15O Ion Beams (2015)
  • Author(s): C. Toramatsu, E. Yoshida, Y. Ikoma, H. Wakizaka, A. Mohammadi, H. Tashima, F. Nishikido, A. Kitagawa, T. Inaniwa, T. Yamaya
  • Organizer: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Town and Country Resort and Convention Center, San Diego
  • Year and Date: 2015-11-05 – 2015-11-05
  • Int'l Joint Research
• [Presentation] 全身用Single-ring OpenPETの開発 (2015)
  • Author(s): 山谷泰賀、吉田英治、田島英朗、錦戸文彦、藤林康久
  • Organizer: 第55回日本核医学会総会
  • Place of Presentation: ハイアットリージェンシー東京
  • Year and Date: 2015-11-05 – 2015-11-05
• [Presentation] Improvement of Purity of Produced 15O Beams for OpenPET (2015)
  • Author(s): A. Mohammadi, E. Yoshida, H. Tashima, F. Nishikido, T. Inaniwa, A. Kitagawa, T. Yamaya
  • Organizer: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
  • Place of Presentation: Town and Country Resort and Convention Center, San Diego
  • Year and Date: 2015-11-04 – 2015-11-04
  • Int'l Joint Research
• [Presentation] 全身用single ring OpenPETの試作 (2015)
  • Author(s): 山谷泰賀, 吉田英治，田島英朗，錦戸文彦，Mohammadi Akram， 新田宗孝，北川敦志，稲庭拓
  • Organizer: 第110回日本医学物理学会学術大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2015-09-19 – 2015-09-19
• [Presentation] シングルリング型ヒトサイズOpenPETの開発 (2015)
  • Author(s): 吉田英治, 田島英朗, 岩男悠真, 錦戸文彦, 新田宗孝, 蛭海元貴, 清水啓司, 稲庭拓, 山谷泰賀
  • Organizer: 第76回応用物理学会秋季学術講演会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-09-16 – 2015-09-16
• [Presentation] PET imaging innovation by DOI detectors (2015)
  • Author(s): Taiga Yamaya
  • Organizer: International Symposium 2015 - Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
  • Place of Presentation: Keio Plaza Hotel Sapporo
  • Year and Date: 2015-07-31 – 2015-07-31
  • Int'l Joint Research / Invited
• [Presentation] Development of a simultaneous optical /PET imaging system for awake mice (2015)
  • Author(s): Hiroyuki Takuwa, Hidekatsu Wakizaka, Eiji Yoshida, Tetsuya Shinaji, Taiga Yamaya, Yoko Ikoma
  • Organizer: The 9th ICME International Conference on Complex Medical Engineering (CME2015)
  • Place of Presentation: Okayama Convention Center
  • Year and Date: 2015-06-20 – 2015-06-20
  • Int'l Joint Research
• [Presentation] PET Innovation: How Imaging Improves Quality of Life (2015)
  • Author(s): Taiga Yamaya
  • Organizer: The 1st International Conference on Advanced Imaging (ICAI2015)
  • Place of Presentation: National Center of Science, Tokyo
  • Year and Date: 2015-06-18 – 2015-06-18
  • Int'l Joint Research / Invited
• [Presentation] Development of flexible data acquisition system with 4-layered DOI detector (2015)
  • Author(s): Eiji Yoshida, Tetsuya Shinaji, Hideaki Tashima, Taiga Yamaya
  • Organizer: SNMMI 2015 Annual Meeting
  • Place of Presentation: Baltimore Convention Center
  • Year and Date: 2015-06-09 – 2015-06-09
  • Int'l Joint Research
• [Presentation] Development of OpenPET for 3D In-beam Particle Therapy Imaging (2015)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, Fumihiko Nishikido, Akram Mohammadi, Tetsuya Shinaji, Munetaka Nitta, Shinji Sato, Taku Inaniwa, Atsushi Kitagawa
  • Organizer: 54th Annual Conference of the Particle Therapy Co-Operative Group (PTCOG 54)
  • Place of Presentation: Manchester Grand Hyatt, San Diego
  • Year and Date: 2015-05-22 – 2015-05-22
  • Int'l Joint Research
• [Presentation] Optimization of produced 15O beam and OpenPET imaging (2015)
  • Author(s): A. Mohammadi, E. Yoshida, H. Tashima, F. Nishikido, T. Shinaji, M. Nitta, T. Inaniwa, A. Kitagawa, T. Yamaya
  • Organizer: 54th Annual Conference of the Particle Therapy Co-Operative Group (PTCOG 54)
  • Place of Presentation: Manchester Grand Hyatt, San Diego
  • Year and Date: 2015-05-22 – 2015-05-22
  • Int'l Joint Research
• [Presentation] Washout effect in Rabbit: in-beam OpenPET measurements using 10C, 11C and 15O ion beams (2015)
  • Author(s): Chie Toramatsu, Eiji Yoshida, Yoko Ikoma, Hidekazu Wakizaka, Akram Mohammadi, Hideaki Tashima, Fumihiko Nishikido, Tetsuya Shinaji, Atsushi Kitagawa, Taku Inaniwa, Taiga Yamaya
  • Organizer: 54th Annual Conference of the Particle Therapy Co-Operative Group (PTCOG 54)
  • Place of Presentation: Manchester Grand Hyatt, San Diego
  • Year and Date: 2015-05-22 – 2015-05-22
  • Int'l Joint Research
• [Presentation] Development of a singlesbased flexible data acquisition system for the OpenPET (2015)
  • Author(s): Eiji Yoshida, Keiji Shimizu, Tetsuya Shinaji, Taiga Yamaya
  • Organizer: 第109回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-18 – 2015-04-18
• [Presentation] Proposed Model of Detector Response Functions using Asymmetric 2D Gaussian Functions and GPU Implementation for the Whole-Body OpenPET (2015)
  • Author(s): Hideaki Tashima, Eiji Yoshida, Tetsuya Shinaji, Taiga Yamaya
  • Organizer: 第109回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-18 – 2015-04-18
• [Presentation] Development of a whole-body OpenPET (2015)
  • Author(s): Taiga Yamaya, Eiji Yoshida, Hideaki Tashima, Naoko Inadama, Fumihiko Nishikido, Tetsuya Shinaji, Munetaka Nitta, Yasunori Nakajima, Shinji Sato, Taku Inaniwa
  • Organizer: 第109回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-17 – 2015-04-17
• [Presentation] First OpenPET imaging of produced 15O ion beams (2015)
  • Author(s): Akram Mohammadi, Eiji Yoshida, Fumihiko Nishikido, Taku Inaniwa, Atsushi Kitagawa, Taiga Yamaya
  • Organizer: 第109回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-17 – 2015-04-17
• [Remarks] 報告書
  • URL: http://www.nirs.go.jp/usr/medical-imaging/ja/study/main.html
• [Remarks] 研究内容紹介
  • URL: http://www.nirs.go.jp/research/division/mic/eng/group/t_imaging-butsuri.html