effect of rehabilitation using mechanical stimuli on articular cartilage and chondrocyte

2017 Fiscal Year Final Research Report

• Project/Area Number: 25242055
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kyoto University
• Principal Investigator: Kuroki Hiroshi 京都大学, 医学研究科, 教授 (20170110)
• Co-Investigator(Kenkyū-buntansha): 伊藤 明良 京都大学, 医学研究科, 助教 (50762134) ; 秋山 治彦 岐阜大学, 大学院医学系研究科, 教授 (60402830) ; 青山 朋樹 京都大学, 医学研究科, 准教授 (90378886) ; 長井 桃子 京都大学, 医学研究科, 研究員 (50755676)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: リハビリテーション / 物理的刺激 / 関節軟骨 / 軟骨細胞

Outline of Final Research Achievements

Purpose of the study was to verify the effect of culture temperature on chondrocyte and extracellular matrix, the effect of application of low-intensity pulsed ultrasound (LIPUS) after mesenchymal stromal cell (MSC) transplantation on regeneration of articular cartilage and subchondral bone, and the effect of treadmill walking (TW) on knee osteoarthritis. The 37 centigrade was effective to generate extracellular matrix, LIPUS was effective after MSC transplantation, and TW increased the expression of Bone Morphogenetic Proteins and prevented the progression of knee OA.

Free Research Field

リハビリテーション、理学療法