2016 Fiscal Year Final Research Report
Screening for Novel Natural Products from Symbiotic Bacteria of Marine Sponge, Halichondria Okadai
| Project/Area Number |
25242069
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kanagawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 天然物 / クロイソカイメン / 生物オリジン / メタゲノム / フローサイトメトリー / SDS-PAGE / 免疫染色 / Symbiodinolide |
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| Outline of Final Research Achievements |
We improved the metagenomic method by converting the library into BAC, shuttle vector. An analysis method of new natural products using SDS-PAGE analysis was constructed. In addition, we developed the origin search method for natural products combining immunostaining method using natural products as antigen and flow cytometry. We further advanced the structural analysis of Symbiodinolide. It is expected to elucidate the symbiotic system by determining the isolation structure of the novel compound by the improved metagenomic method and identifying the origin of these natural products.
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| Free Research Field |
天然物化学、ケミカルバイオロジー
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