Creation of novel drug nanoparticles based on the conventional reverse molecular design using poor water-soluble compounds and the efficacy evaluation

2016 Fiscal Year Final Research Report

• Project/Area Number: 25248044
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Organic and hybrid materials
• Research Institution: Tohoku University
• Principal Investigator: KASAI HITOSHI 東北大学, 多元物質科学研究所, 教授 (30312680)
• Co-Investigator(Kenkyū-buntansha): 中澤 徹 東北大学, 医学(系)研究科(研究院), 教授 (30361075) ; 村上 達也 京都大学, 物質－細胞統合システム拠点, 准教授 (90410737)
• Co-Investigator(Renkei-kenkyūsha): OIKAWA Hidetoshi 東北大学, 多元物質科学研究所, 教授 (60134061)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ナノ薬剤 / 再沈法 / 抗癌薬 / 点眼薬

Outline of Final Research Achievements

In this project, we introduced a new concept of introducing a poorly water-soluble substituent into anticancer medicinal compounds. Next, we synthesized them and then created the drug nanoparticles by using our own technique of the reprecipitation method. And, it was found that, by covering polymers or proteins on these drug nanoparticles, dispersion stability of the nanodrug could be improved. In vivo experiment, it was revealed that the nanodrugs could be delivered into the inside of cells of the tumor tissue. And this technique could be applied as eye drops including the glaucoma and so on.

Free Research Field

有機材料化学