Roles of TTF-1/NKX2-1 lineage-survival oncogene in lung adenocarcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25250017
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Nagoya University
• Principal Investigator: Takahashi Takashi 名古屋大学, 医学(系)研究科(研究院), 教授 (50231395)
• Co-Investigator(Kenkyū-buntansha): MIYANO Satoru 東京大学, 医科学研究所, 教授 (50128104) ; YANAGISAWA Kiyoshi 名古屋大学, 大学院医学系研究科, 講師 (20372112)
• Co-Investigator(Renkei-kenkyūsha): ASAI Naoya 名古屋大学, 大学院医学系研究科, 准教授 (80273233)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 癌 / シグナル伝達 / システム生物学

Outline of Final Research Achievements

This study has demonstrated that ROR plays a crucial role as a “sustainer” receptor tyrosine kinase (RTK) in the molecular pathogenesis of lung adenocarcinoma through establishment of Ror1 conditional knockout mice exhibiting mutant EGFR-driven tumorigenesis. We have also found that ROR1 sustains survival signaling of multiple RTKs by maintaining CAV1 expression and caveolae structure. Finally, a novel gene, MXTN, modulating TTF-1-mediated transcriptional regulation, was identified through a combined approach employing both systems biologic and cancer biologic analyses.

Free Research Field

腫瘍生物学