Comprehensive understanding of molecular carcinogenesis through omics analysis and development of molecular diagnostics for personalized medicine

2015 Fiscal Year Final Research Report

• Project/Area Number: 25250019
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor diagnostics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Johji Inazawa 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
• Co-Investigator(Kenkyū-buntansha): Kozaki Ken-ichi 岡山大学, 医歯薬学総合研究科, 教授 (50270715) ; Inoue Jun 東京医科歯科大学, 難治疾患研究所, 講師 (50568326) ; Tanimoto Kosuke 東京医科歯科大学, 難治疾患研究所, 助教 (60611613) ; Muramatsu Tomoki 東京医科歯科大学, 難治疾患研究所, 助教 (90732553)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん個別化医療 / オミクス解析 / 上皮間葉転換 / p62 / マイクロRNA / バイオマーカー / 治療標的 / オートファジー

Outline of Final Research Achievements

The principle aim of this research project is to understand the molecular mechanism underlying intractable cancer and to contribute to the development of molecular target-therapy and diagnosis for the personalized cancer medicine. Our achievements of the project as follows; (1) The hypusine cascade involved in protein synthesis was identified as a novel cancer therapeutic target. (2) Using function-based screening we identified a novel EMT-inducing microRNA, miR-544a in gastric cancer cell line. (3) We found that high expression of p62 is associated with poor prognosis in endometrial cancers. (4) Overexpression of miR-634 activates the mitochondrial apoptotic pathway, indicating the utility of miR-634 therapy against NRF2-activated tumors.

Free Research Field

分子腫瘍学