Identification of targetable oncogenes using histopathological approaches

2015 Fiscal Year Final Research Report

• Project/Area Number: 25250020
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor diagnostics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: TAKEUCHI KENGO 公益財団法人がん研究会, 分子標的病理プロジェクト, 研究員 (40323612)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: チロシンキナーゼ / 融合遺伝子

Outline of Final Research Achievements

During the study period, more than 100,000 FISH screenings were performed in lung cancer, gynecological cancer, breast cancer, colon cancer, pancreatic cancer, head and neck cancer, and lymphoma. Several fusion genes were identified (unpublished) in gynecological cancer, colon cancer, pancreatic cancer and head and neck cancer and lymphoma.
Genetic abnormalities were comprehensively examined and reported in various lymphomas. Transgenic mice simulating ROS1-positive lung cancer was developed and reported with the results of experiments using ROS1 inhibitors. Novel resistant mechanisms in ALK-positive lung cancer were reported. Clinical trials using corresponding inhibitors were performed for the patients with RET-positive lung cancer or ALK-positive lung cancer, in which I took charge of a central diagnosis. Several recommendations about the diagnosis of ALK-positive lung cancer were made.

Free Research Field

人体病理学