Efficient Synthesis of Natural Products Useful for Drug Discovery Based on Innovative Synthetic Methodologies

2015 Fiscal Year Final Research Report

• Project/Area Number: 25253002
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Nagasaki University
• Principal Investigator: HATAKEYAMA Susumi 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (20143000)
• Co-Investigator(Kenkyū-buntansha): ISHIHARA JUN 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (80250413) ; TAKAHASHI KEISUKE 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (60380854)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 合成化学 / 全合成 / 天然物

Outline of Final Research Achievements

We have studied on the total synthesis of natural products having intriguing structures and biological activities useful for drug discovery. As a result, we have achieved the total syntheses of lajollamycin B and N-methylwelwitindolinone C isothiocyanate. In addition, we have developed a new methodology for tetrahydrofuran synthesis which relies on a Rh(II)/Zn(II)-catalyzed [4 + 1]-cycloaddition reaction of a homopropargyl alcohol, and have achieved the total syntheses of cinatrin C1, ophiodilactones A and B, and marinomycin A.

Free Research Field

有機合成化学