2017 Fiscal Year Final Research Report
The novel post-transcriptional regulation mechanism of antiviral host defense
| Project/Area Number |
25253030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Takaoka Akinori 北海道大学, 遺伝子病制御研究所, 教授 (30323611)
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| Project Period (FY) |
2013-04-01 – 2018-03-31
|
| Keywords | 自然免疫 / ウイルス感染 / 抗ウイルス効果 / RNA転写後制御 |
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| Outline of Final Research Achievements |
Viral infection is one of the most critical problems for our health. Elucidation of host immune response against invading viruses is crucial for better understanding of the pathological processes and viral elimination to control viral infection. In this study, we reveal that PARP-13 shorter isoform (ZAPS) is involved in the post-transcriptional regulation of RSAD2 mRNA, one of the interferon-stimulated genes, which provide a novel host defense mechanism for elimination of viruses.
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| Free Research Field |
免疫学
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