Epidemiological study of stroke, dementia, and depression based on brain MRI in an elderly population: the Hisayama Study

2015 Fiscal Year Final Research Report

• Project/Area Number: 25253048
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: Yutaka Kiyohara 九州大学, 医学(系)研究科(研究院), 教授 (80161602)
• Co-Investigator(Kenkyū-buntansha): KANBA Shigenobu 九州大学, 大学院医学研究院, 教授 (50195187) ; KITAZONO Takanari 九州大学, 大学院医学研究院, 教授 (70284487) ; NINOMIYA Toshiharu 九州大学, 大学院医学研究院, 教授 (30571765) ; HATA Jun 九州大学, 大学院医学研究院, 准教授 (00448432) ; OHARA Tomoyuki 九州大学, 大学院医学研究院, 助教 (20623630) ; KOKUBO Yosihhiro 独立行政法人国立循環器病研究センター, 医長 (20393217)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 頭部MRI / 糖尿病 / 脳萎縮 / 海馬萎縮 / アルツハイマー病 / 微小脳出血

Outline of Final Research Achievements

(1) Association of diabetes mellitus with brain and hippocampal atrophy in the elderly: We examined the association between diabetes-related parameters and morphological changes in the brain using the MRI data from the residents of Hisayama, Fukuoka, aged 65 years or older in 2012-2013. Diabetes was a significant risk factor for brain atrophy, particularly hippocampal atrophy. A longer duration of diabetes and elevated 2-hour postload glucose levels were significantly associated with smaller hippocampal volume.
(2) Prevalence of cerebral microbleeds (CMBs) in the elderly: The prevalence of CMBs in the Hisayama residents aged 65 years or older was 19%. The prevalence was significantly higher in men than in women, and increased significantly with aging.

Free Research Field

生活習慣病の疫学研究