家庭血圧に基づく高血圧発症・降圧薬反応性を規定する遺伝要因に関する疫学・介入研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 25253059
• Research Institution: Tohoku University
• Principal Investigator: 今井 潤 東北大学, 薬学研究科(研究院), 教授 (40133946)
• Co-Investigator(Kenkyū-buntansha): 三木 哲郎 京都大学, 医学(系)研究科(研究院), 教授 (00174003) ; 田原 康玄 京都大学, 医学(系)研究科(研究院), 准教授 (00268749) ; 樂木 宏実 大阪大学, 医学(系)研究科(研究院), 教授 (20252679) ; 勝谷 友宏 大阪大学, 医学(系)研究科(研究院), 准教授 (30311757) ; 大久保 孝義 帝京大学, 医学部, 教授 (60344652) ; 野出 孝一 佐賀大学, 医学部, 教授 (80359950) ; 神出 計 大阪大学, 医学(系)研究科(研究院), 教授 (80393239) ; 河野 雄平 帝京大学, 福岡医療技術学部, 教授 (90118076) ; 三浦 克之 滋賀医科大学, 医学部, 教授 (90257452)
• Project Period (FY): 2013-05-31 – 2016-03-31
• Keywords: 社会医学 / 循環器・高血圧 / 遺伝子 / 臨床薬理学 / 遺伝子疫学

Outline of Annual Research Achievements

平成27年度は、高血圧関連遺伝子の探索に際して、新たにハプロタイプブロック情報をモデルに投入した新しい関連性分析を実施した。これは、 がん遺伝子を対象とした研究を通じて、単一遺伝子変異 (SNP)ごとの解析だけでは、重要な関連遺伝子を見落とす可能性があると報告されているためである (J Hum Genetics 2007;52:738)。本解析対象は、先に学術発表した論文に従い (Kamide K, et al. Pharmacogenomics 2013;14:1709)、降圧度と関連するハプロタイプを線形回帰分析にて求めた。その結果、アンギオテンシンII受容体拮抗薬 (ARB)群において、収縮期・拡張期 HBPそれぞれの降圧と PMAIP1 (rs1942919)が、収縮期 HBPの降圧と PPARGC1A (rs9291457)か、各々強く関連した。一方、既報の候補遺伝子の中では、YIPF1に関して関連性が認められた (p=0.0001)。PMAIP1とPPARGC1Aは、いずれも遺伝子の上流または下流の領域のハプロタイプであったが、既報の論文解析では未検出であり、ハプロタイプブロックを用いた解析によって見落とされていた関連遺伝子が発見される可能性が、循環器領域においても示された。
一方、同じ HOMED-BP研究集団を用いて、血圧の日間変動ならびに白衣・仮面高血圧に関連する遺伝子を、共同研究者の協力を得て遺伝情報を補完した 689万SNPsとの関連性について分析した。その結果、いくつかの関連遺伝子が同定された。研究期間終了に間に合わなかったが、本結果は大迫研究集団を用いたreplication studyを実施後、早期の論文化を予定している。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Synergistic association of elevated serum free fatty acid and glucose levels with large arterial stiffness in a general population: The Nagahama Study. (2016)
  • Author(s): Tabara Y, Takahashi Y, Setoh K, Kawaguchi T, Gotoh N, Terao C, Yamada R, Kosugi S, Sekine A, Nakayama T, Matsuda F; Nagahama Study group.
  • Journal Title: METABOLISM Volume: 65 Pages: 66～72
  • DOI: 10.1016/j.metabol.2015.10.011
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of the second derivative of the finger photoplethysmogram for assessment of end-organ damage: the J-SHIPP study. (2016)
  • Author(s): Tabara Y, Igase M, Okada Y, Nagai T, Miki T, Ohyagi Y, Matsuda F, Kohara K.
  • Journal Title: HYPERTENSION RESEARCH Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1038/hr.2016.18
  • Peer Reviewed
• [Journal Article] Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension. (2016)
  • Author(s): Morris BJ, Chen R, Donlon TA, Evans DS, Tranah GJ, Parimi N, Ehret GB, Newton-Cheh C, Seto T, Willcox DC, Masaki KH, Kamide K, Ryuno H, Oguro R, Nakama C, Kabayama M, Yamamoto K, Sugimoto K, Ikebe K, Masui Y, Arai Y, Ishizaki T, Gondo Y, Rakugi H, Willcox BJ.
  • Journal Title: AMERICAN JOURNAL OF HYPERTENSION Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1093/ajh/hpv171
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of calcium channel blocker-based combinations on intra-individual blood pressure variability: post hoc analysis of the COPE trial. (2016)
  • Author(s): Umemoto S, Ogihara T, Matsuzaki M, Rakugi H, Ohashi Y, Saruta T; Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial Group; Combination Therapy of Hypertension to Prevent Cardiovascular Events COPE Trial Group.
  • Journal Title: HYPERTENSION RESEARCH Volume: 39 Pages: 46～53
  • DOI: 10.1038/hr.2015.104
  • Peer Reviewed / Open Access
• [Journal Article] Age and sex differences in the taste sensitivity of young adult， young-old and old-old Japanese. (2016)
  • Author(s): Yoshinaka M, Ikebe K, Uota M, Ogawa T, Okada T, Inomata C, Takeshita H, Mihara Y, Gondo Y, Masui Y, Kamide K, Arai Y, Takahashi R, Maeda Y.
  • Journal Title: GERIATRICS & GERONTOLOGY INTERNATIONAL Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1111/ggi.12638
  • Peer Reviewed / Open Access
• [Journal Article] Association of occlusal force with cognition in independent older Japanese people. (2016)
  • Author(s): Takeshita H, Ikebe K, Gondo Y, Inagaki H, Masui Y, Inomata C, Mihara Y, Uota M, Matsuda K, Kamide K, Takahashi R, Arai Y, Maeda Y.
  • Journal Title: JDR CLINICAL & TRANSLATIONAL RESEARCH Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1177/2380084416636604
  • Peer Reviewed / Open Access
• [Journal Article] Differences of Association between High Blood Pressure and Cognitive Functioning among General Japanese Population Aged 70 and 80 Years: The SONIC Study. (2016)
  • Author(s): Ryuno H, Kamide K, Gondo Y, Nakama C, Oguro R, Kabayama M, Kawai T, Kusunoki H, Yokoyama S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Yamamoto K, Takeya Y, Sugimoto K, Nakagawa T, Ikebe K, Inagaki H, Masui Y, Ishizaki T, Takayama M, Arai Y, Takahashi R, Rakugi H.
  • Journal Title: HYPERTENSION RESEARCH Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1038/hr.2016.25
  • Peer Reviewed
• [Journal Article] Differential effects of angiotensin II receptor blocker and losartan/hydrochlorothiazide combination on central blood pressure and augmentation index. (2015)
  • Author(s): Metoki H, Obara T, Asayama K, Satoh M, Hosaka M, Elnagar N, Miyawaki Y, Kojima I, Ohkubo T, Imai Y for the Japan-Home versus Office Blood Pressure Measurement Evaluation-Augmentation Index Study Investigators.
  • Journal Title: CLINICAL AND EXPERIMENTAL HYPERTENSION Volume: 37 Pages: 294～302
  • DOI: 10.3109/10641963.2014.960972
  • Peer Reviewed
• [Journal Article] Association of aldosterone-to-renin ratio with hypertension differs by sodium intake: The Ohasama Study. (2015)
  • Author(s): Satoh M, Kikuya M, Hosaka M, Asayama K, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Mori T, Totsune K, Hoshi H, Mano N, Imai Y, Ohkubo T.
  • Journal Title: AMERICAN JOURNAL OF HYPERTENSION Volume: 28 Pages: 208～215
  • DOI: 10.1093/ajh/hpu115
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optimal Number of Days for Home Blood Pressure Measurement. (2015)
  • Author(s): Niiranen TJ, Asayama K, Thijs L, Johansson JK, Hara A, Hozawa A, Tsuji I, Ohkubo T, Jula AM, Imai Y, Staessen JA; IDHOCO Investigators.
  • Journal Title: AMERICAN JOURNAL OF HYPERTENSION Volume: 28 Pages: 595～603
  • DOI: 10.1093/ajh/hpu216
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combined Effect of Blood Pressure and Total Cholesterol Levels on Long-Term Risks of Subtypes of Cardiovascular Death: Evidence for Cardiovascular Prevention From Observational Cohorts in Japan. (2015)
  • Author(s): Satoh M, Ohkubo T, Asayama K, Murakami Y, Sakurai M, Nakagawa H, Iso H, Okayama A, Miura K, Imai Y, Ueshima H, Okamura T; on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group.
  • Journal Title: HYPERTENSION Volume: 65 Pages: 517～524
  • DOI: 10.1161/HYPERTENSIONAHA.114.04639
  • Peer Reviewed / Open Access
• [Journal Article] [8-OR]: Blood pressure and heart rate among pregnant women before and after the Great East Japan Earthquake (March 11, 2011) in the BOSHI study. (2015)
  • Author(s): Metoki H, Iwama N, Watanabe Z, Ohkubo T, Ishikuro M, Obara T, Kikuya M, Sugawara J, Kuriyama S, Itoh K, Hoshi K, Suzuki M, Satoh M, Yaegashi N, Imai Y.
  • Journal Title: PREGNANCY HYPERTENSION Volume: 5 Pages: 4～5
  • DOI: 10.1016/j.preghy.2014.10.012
  • Peer Reviewed / Open Access
• [Journal Article] Living situations associated with poor dietary intake among healthy Japanese elderly: the Ohasama study. (2015)
  • Author(s): Tsubota-Utsugi M, Kikuya M, Satoh M, Inoue R, Hosaka M, Metoki H, Hirose T, Asayama K, Imai Y, Ohkubo T.
  • Journal Title: THE JOURNAL OF NUTRITION, HEALTH & AGING Volume: 19 Pages: 375～382
  • DOI: 10.1007/s12603-015-0456-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metabolic responses during hemodialysis determined by quantitative 1H NMR spectroscopy. (2015)
  • Author(s): Fujiwara M, Ando I, Takeuchi K, Oguma S, Sato H, Sekino H, Sato K, Imai Y.
  • Journal Title: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS Volume: 111 Pages: 159～162
  • DOI: 10.1016/j.jpba.2015.03.035
  • Peer Reviewed / Open Access
• [Journal Article] Awareness of the Japanese Society of Hypertension Guidelines for the Management of Hypertension and their use in clinical practices: 2009 survey results. (2015)
  • Author(s): Obara T, Ubeda SR, Ohkubo T, Matsuura H, Ishimitsu T, Takata M, Rakugi H, Imai Y on behalf of Japanese Society of Hypertension Recurrent Education Committee.
  • Journal Title: HYPERTENSION RESEARCH Volume: 38 Pages: 400～404
  • DOI: 10.1038/hr.2015.21
  • Peer Reviewed
• [Journal Article] Differences between clinic and home blood pressure measurements during pregnancy. (2015)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Kikuya M, Yaegashi N, Kuriyama S, Imai Y.
  • Journal Title: JOURNAL OF HYPERTENSION Volume: 33 Pages: 1492～1493
  • DOI: 10.1097/HJH.0000000000000608
  • Peer Reviewed
• [Journal Article] Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study. (2015)
  • Author(s): Satoh M, Hosaka M, Asayama K, Kikuya M, Inoue R, Metoki H, Tsubota-Utsugi M, Hara A, Hirose T, Obara T, Totsune K, Hoshi H, Mano N, Node K, Imai Y, Ohkubo T.
  • Journal Title: JOURNAL OF HYPERTENSION Volume: 33 Pages: 1536～1541
  • DOI: 10.1097/HJH.0000000000000570
  • Peer Reviewed
• [Journal Article] Impacts of the Great East Japan Earthquake on diabetic patients. (2015)
  • Author(s): Tanaka M, Imai J, Satoh M, Hashimoto T, Izumi T, Sawada S, Uno K, Hasegawa Y, Kaneko K, Yamada T, Ishigaki Y, Imai Y, Katagiri H.
  • Journal Title: JOURNAL OF DIABETES INVESTIGATION Volume: 6 Pages: 577～586
  • DOI: 10.1111/jdi.12336
  • Peer Reviewed / Open Access
• [Journal Article] Defining thresholds for home blood pressure monitoring in octogenarians. (2015)
  • Author(s): Aparicio LS, Thijs L, Boggia J, Jacobs L, Barochiner J, Odili AN, Alfie J, Asayama K, Cuffaro PE, Nomura K, Ohkubo T, Tsuji I, Stergiou GS, Kikuya M, Imai Y, Waisman GD, Staessen JA; International Database on Home Blood Pressure in Relation to Cardiovascular Outcome (IDHOCO) Investigators.
  • Journal Title: HYPERTENSION Volume: 66 Pages: 865～873
  • DOI: 10.1161/HYPERTENSIONAHA.115.05800
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Salt intake and the validity of a salt intake assessment system based on a 24-h dietary recall method in pregnant Japanese women. (2015)
  • Author(s): Satoh M, Tanno Y, Hosaka M, Metoki H, Obara T, Asayama K, Hoshi K, Suzuki M, Mano N, Imai Y.
  • Journal Title: CLINICAL AND EXPERIMENTAL HYPERTENSION Volume: 37 Pages: 459～462
  • DOI: 10.3109/10641963.2013.863319
  • Peer Reviewed
• [Journal Article] Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide. (2015)
  • Author(s): Hosaka M, Metoki H, Satoh M, Ohkubo T, Asayama K, Kikuya M, Inoue R, Obara T, Hirose T, Imai Y on behalf of The J-HOME-CARD Study group.
  • Journal Title: HYPERTENSION RESEARCH Volume: 38 Pages: 701～707
  • DOI: 10.1038/hr.2015.64
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. (2015)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Iwama N, Katagiri M, Nishigori H, Narikawa Y, Yagihashi K, Kikuya M, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y.
  • Journal Title: HYPERTENSION RESEARCH Volume: 38 Pages: 770～775
  • DOI: 10.1038/hr.2015.97
  • Peer Reviewed
• [Journal Article] Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development. (2015)
  • Author(s): Hosaka M, Asayama K, Staessen JA, Tatsuta N, Satoh M, Kikuya M, Ohkubo T, Satoh H, Imai Y, Nakai K.
  • Journal Title: HYPERTENSION RESEARCH Volume: 38 Pages: 776～782
  • DOI: 10.1038/hr.2015.97
  • Peer Reviewed
• [Journal Article] Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis. (2015)
  • Author(s): Sundstrom J, Arima H, Jackson R, Turnbull F, Rahimi K, Chalmers J, Woodward M, Neal B; Blood Pressure Lowering Treatment Trialists' Collaboration (HOMED-BP;Ohkubo T, Imai Y).
  • Journal Title: ANNALS OF INTERNAL MEDICINE Volume: 162 Pages: 184～191
  • DOI: 10.7326/M14-0773
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with blood pressure level: the Nagahama study. (2015)
  • Author(s): Tabara Y, Takahashi Y, Kumagai K, Setoh K, Kawaguchi T, Takahashi M, Muraoka Y, Tsujikawa A, Gotoh N, Terao C, Yamada R, Kosugi S, Sekine A, Yoshimura N, Nakayama T, Matsuda F; Nagahama study group.
  • Journal Title: JOURNAL OF HYPERTENSION Volume: 33 Pages: 2407～2413
  • DOI: 10.1097/HJH.0000000000000734
  • Peer Reviewed
• [Journal Article] Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels. (2015)
  • Author(s): Setoh K, Terao C, Muro S, Kawaguchi T, Tabara Y, Takahashi M, Nakayama T, Kosugi S, Sekine A, Yamada R, Mishima M, Matsuda F.
  • Journal Title: NATURE COMMUNICATIONS Volume: 6 Pages: 7754
  • DOI: 10.1038/ncomms8754
  • Peer Reviewed / Open Access
• [Journal Article] Reliability of measurement of endothelial function across multiple institutions and establishment of reference values in Japanese. (2015)
  • Author(s): Tomiyama H, Kohro T, Higashi Y, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Watanabe K, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Ikeda H, Yamashina A.
  • Journal Title: ATHEROSCLEROSIS Volume: 242 Pages: 433～442
  • DOI: 10.1016/j.atherosclerosis.2015.08.001
  • Peer Reviewed / Open Access
• [Journal Article] Choice of Antihypertensive Combination Therapy Based on Daily Salt Intake. (2015)
  • Author(s): Toyoda S, Inami S, Kato T, Tsukada K, Nakamoto A, Kikegawa Y, Suzuki A, Anraku Y, Node K, Inoue T.
  • Journal Title: THE AMERICAN JOURNAL OF THE MEDICAL SCIENCE Volume: 350 Pages: 160～166
  • DOI: 10.1097/MAJ.0000000000000529
  • Peer Reviewed
• [Journal Article] Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. (2015)
  • Author(s): Kato N, Takeuchi F, Tabara Y, Katsuya T, Kohara K, Matsubara T, Matsushita Y, Meitinger T, Ohkubo T, Rakugi H, Rolandsson O, Ueshima H, Linneberg A, Miki T, Toniolo D; BIOS-consortium; CARDIo GRAMplusCD; LifeLines Cohort Study; InterAct Consortium, Ahsan H, Kooner JS, Chambers JC, et al.
  • Journal Title: NATURE GENETICS Volume: 47 Pages: 1282～1293
  • DOI: 10.1038/ng.3405
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mapping the genetic diversity of HLA haplotypes in the Japanese populations. (2015)
  • Author(s): Saw WY, Liu X, Khor CC, Takeuchi F, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Yamamoto K, Yokota M; Japanese Genome Variation Consortium, Teo YY, Kato N.
  • Journal Title: SCIENTIFIC REPORTS Volume: 5 Pages: 17855
  • DOI: 10.1038/srep17855
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. (2015)
  • Author(s): Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H.
  • Journal Title: THE FASEB JOURNAL Volume: 29 Pages: 3342～3356
  • DOI: 10.1096/fj.15-271627
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Add-on effect of hydrochlorothiazide 12.5 mg in Japanese subjects with essential hypertension uncontrolled with losartan 50 mg and amlodipine 5 mg. (2015)
  • Author(s): Rakugi H, Tsuchihashi T, Shimada K, Numaguchi H, Nishida C, Yamaguchi H, Shirakawa M, Azuma K, Fujita KP.
  • Journal Title: HYPERTENSION RESEARCH Volume: 38 Pages: 329～335
  • DOI: 10.1038/hr.2015.3
  • Peer Reviewed
• [Journal Article] Low alpha-synuclein levels in the blood are associated with insulin resistance. (2015)
  • Author(s): Rodriguez-Araujo G, Nakagami H, Takami Y, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Morishita R, Rakugi H, Kaneda Y.
  • Journal Title: SCIENTIFIC REPORTS Volume: 5 Pages: 12081
  • DOI: 10.1038/srep12081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-term reduction of high blood pressure by angiotensin II DNA vaccine in spontaneously hypertensive rats. (2015)
  • Author(s): Koriyama H, Nakagami H, Nakagami F, Osako MK, Kyutoku M, Shimamura M, Kurinami H, Katsuya T, Rakugi H, Morishita R.
  • Journal Title: HYPERTENSION Volume: 66 Pages: 167-174
  • DOI: 10.1161/HYPERTENSIONAHA.114.04534
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneous effects of association between blood pressure Loci and coronary artery disease in East Asian individuals. (2015)
  • Author(s): Takeuchi F, Isono M, Yamamoto K, Yokota M, Akiyama K, Katsuya T, Kim HS, Park JE, Jang Y, Lee JY; AGEN Consortium, Lee JY, Kato N.
  • Journal Title: CIRCULATION JOURNAL Volume: 79 Pages: 830-838
  • DOI: 10.1253/circj.CJ-14-0841
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of personality traits with oral health-related quality of life independently of objective oral health status: A study of community-dwelling elderly Japanese. (2015)
  • Author(s): Takeshita H, Ikebe K, Kagawa R, Okada T, Gondo Y, Nakagawa T, Ishioka Y, Inomata C, Tada S, Matsuda K, Kurushima Y, Enoki K, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y.
  • Journal Title: JOURNAL OF DENTISTRY Volume: 43 Pages: 342～349
  • DOI: 10.1016/j.jdent.2014.12.011
  • Peer Reviewed / Open Access
• [Journal Article] The association between lower occlusal force and slower walking speed mediated by less protein intake: from SONIC study. (2015)
  • Author(s): Okada T, Ikebe K, Kagawa R, Inomata C, Takeshita H, Gondo Y, Ishioka Y, Okubo H, Kamide K， Masui Y, Takahashi R, Arai A, W. Murray Thomson WM, Maeda Y.
  • Journal Title: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Volume: 63 Pages: 2382～2387
  • DOI: 10.1111/jgs.13784
  • Peer Reviewed / Open Access
• [Presentation] Genome-wide Association Study of Day-to-day Blood Pressure Variability in Pre-treated Hypertensive Patients: The HOMED-BP Study (2016)
  • Author(s): 大久保孝義、佐藤倫広、浅山敬、神出計、田原康玄、尾形宗士郎、杉本研、勝谷友宏、樂木宏実、今井潤、HOMED-BP study group
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: せんだい青葉山交流広場（宮城県仙台市）
  • Year and Date: 2016-03-19
• [Presentation] 閉経後女性における生殖関連要因と 脳卒中発症との関連：大迫研究 (2016)
  • Author(s): 村上慶子、佐藤倫広、浅山敬、保坂実樹、松田彩子、井上隆輔、目時弘仁、坪田恵、菊谷昌浩、村上任尚、今井潤、大久保孝義
  • Organizer: 第26回日本疫学会学術総会
  • Place of Presentation: 米子コンベンションセンター（鳥取県米子市）
  • Year and Date: 2016-01-22
• [Presentation] 70歳前期高齢者における高血圧と認知機能低下との関連-SONIC研究3年間の追跡調査からの知見- (2015)
  • Author(s): 龍野洋慶、神出計、権藤恭之、小黒亮輔、中間千香子、樺山舞、池邉一典、新井康通、石崎達郎、樂木宏実
  • Organizer: 第26回日本老年医学会近畿地方会
  • Place of Presentation: 京都府立医科大学基礎医学学舎・図書館ホール（京都府京都市）
  • Year and Date: 2015-11-14
• [Presentation] Apoptosis Inhibitor of Macrophage Activates Inflammatory Response After Acute Myocardial Infarction American Heart Association Scientific Sessions. (2015)
  • Author(s): Nishikido T, Oyama J, Shiraki A, Komoda H, Node K.
  • Organizer: American Heart Association Scientific Sessions.
  • Place of Presentation: Orlando (United States)
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] 家庭血圧を用いた震災後の血圧管理の重要性とその対策 震災時の高血圧対策： 我々はどうすべきか -これまでの経緯を踏まえて (2015)
  • Author(s): 佐藤倫広、目時弘仁、浅山敬、菊谷昌浩、眞野成康、大久保孝義、今井潤
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-11
• [Presentation] 古典的な血圧関連遺伝子の現在における位置づけについて (2015)
  • Author(s): 勝谷友宏、森下竜一、樂木宏実
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-11
• [Presentation] 高齢期における動脈硬化進展リスクの検討-SONIC研究3年間の追跡調査からの知見- (2015)
  • Author(s): 龍野洋慶、神出計、中間千香子、樺山舞、小黒亮輔、横山世理奈、武田昌生、伊東範尚、鷹見洋一、竹屋美幸、竹屋泰、山本浩一、杉本研、樂木宏実
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-09 – 2015-10-11
• [Presentation] Association of Longevity Gene Polymorphism, FOXO3A SNP, with Hypertension in Japanese Older Subjects -SONIC Study- (2015)
  • Author(s): Kamide K, Ryuno H, Oguro R, Nakama C, Yokoyama S, Kabayama M, Takeya M, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Rakugi H
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館（愛媛県松山市）
  • Year and Date: 2015-10-09 – 2015-10-11
• [Presentation] Lack of association between HbA1c and cardiovascular outcome in Japanese type 2 diabetic patients with coronary artery disease. (2015)
  • Author(s): Ueda S, Morimoto T, Node K.
  • Organizer: European Society of Cardiology.
  • Place of Presentation: London (United Kingdom)
  • Year and Date: 2015-08-29 – 2015-09-02
  • Int'l Joint Research
• [Presentation] 高齢者における高血圧と認知機能との関連－服薬アドヒアランスの影響：SONIC研究－ (2015)
  • Author(s): 龍野洋慶、神出計、権藤恭之、小黒亮輔、中間千香子、横山世理奈、中川威、樺山舞、杉本研、池邉一典、新井康通、増井幸恵、石崎達郎、樂木宏実
  • Organizer: 第51回日本循環器病予防学会学術集会
  • Place of Presentation: 大阪大学中之島センター（大阪府大阪市）
  • Year and Date: 2015-06-26 – 2015-06-27
• [Presentation] Seasonal variation in home blood pressure among patients under antihypertensive medication: HOMED-BP Study. (2015)
  • Author(s): Hanazawa T, Asayama K, Metoki H, Obara T, Inoue R, Kikuya M, Satoh M, Hosaka M, Yasui D, Ohkubo T, Imai Y, HOMED-BP Study Group
  • Organizer: 25th European Meeting on Hypertension and Cardiovascular Protection (ESH)
  • Place of Presentation: Milan (Italy)
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] 高齢者高血圧治療における降圧薬感受性遺伝子の関与-SONIC研究- (2015)
  • Author(s): 神出計、小栗亮輔、中間千香子、横山世里奈、龍野洋慶、樺山舞、杉本研、池邉一典、権藤恭之、樂木宏実
  • Organizer: 第57回日本老年医学会学術集会・総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-13
• [Presentation] 高齢者における高血圧と認知機能との関連－服薬アドヒアランスの影響：SONIC研究－ (2015)
  • Author(s): 龍野洋慶、神出計、権藤恭之、小黒亮輔、中間千香子、樺山舞、池邉一典、新井康通、石崎達郎、樂木宏実
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-12 – 2015-06-14
• [Presentation] 高齢者における飲酒と血圧の関連（SONIC研究） (2015)
  • Author(s): 福崎円香、神出計、樺山舞、龍野洋慶、奈古由美子、清重映里、中間千香子、小黒亮輔、杉本研、池邉一典、石崎達郎、新井康通、権藤恭之、樂木宏実
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-06-12 – 2015-06-14
• [Presentation] 塩分チェックシートを用いた高齢期における高血圧と塩分摂取状況との関連（SONIC研究） (2015)
  • Author(s): 龍野洋慶、神出計、樺山舞、渡邉智絵、奈古由美子、福崎円香、清重映里、小黒亮輔、中間千香子、横山世理奈、杉本研、池邉一典、権藤恭之、樂木宏実
  • Organizer: 第4回臨床高血圧フォーラム
  • Place of Presentation: アクロス福岡（福岡県福岡市）
  • Year and Date: 2015-05-23 – 2015-05-24
• [Presentation] 電子血圧計を用いた客観的な高血圧治療に関する研究（HOMED-BP研究）参加主治医に関する質問表調査 (2015)
  • Author(s): 安井大策、浅山敬、佐藤倫広、保坂実樹、花澤智大、渡部大介、大久保孝義、今井潤、HOMED-BP研究グループ
  • Organizer: 第4回臨床高血圧フォーラム
  • Place of Presentation: アクロス福岡（福岡県福岡市）
  • Year and Date: 2015-05-23
• [Presentation] Association between Hypertension and Cognitive Function in Age 70 and 80 Years from Japanese SONIC Study (2015)
  • Author(s): Ryuno H, Kamide K, Gondo Y, Oguro R, Nakama C, Ikebe K, Masui Y, Ishizaki T, Arai Y, Rakugi H
  • Organizer: The International Association of Gerontology and Geriatrics European Region 8th Congress
  • Place of Presentation: Dublin(Ireland)
  • Year and Date: 2015-04-23 – 2015-04-26
  • Int'l Joint Research
• [Presentation] Effects of Anti-hypertensive Medication on Cognitive Function in Older Subjects: The SONIC Study (2015)
  • Author(s): Ryuno H, Kamide K, Gondo Y, Nakama C, Oguro R, Kabayama M, Ikebe K, Masui Y, Inagaki H, Ishizaki T, Arai Y, Rakugi H
  • Organizer: The International Association of Gerontology and Geriatrics European Region 8th Congress
  • Place of Presentation: Dublin (Ireland)
  • Year and Date: 2015-04-23 – 2015-04-26
  • Int'l Joint Research