Population studies regarding genetic background on progression of hypertension and antihypertensive drug effect based on self-measured home blood pressure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25253059
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Imai Yutaka 東北大学, 薬学研究科(研究院), 教授 (40133946)
• Co-Investigator(Kenkyū-buntansha): MIKI Tetsuro 京都大学, 医学研究科, 特任教授 (00174003) ; TABARA Yasuharu 京都大学, 大学院医学研究科, 准教授 (00268749) ; RAKUGI Hiromi 大阪大学, 大学院医学系研究科, 教授 (20252679) ; KATSUYA Tomohiro 大阪大学, 大学院医学系研究科, 特任准教授 (30311757) ; OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652) ; NODE Koichi 佐賀大学, 医学部, 教授 (80359950) ; KAMIDE Kei 大阪大学, 大学院医学系研究科, 教授 (80393239) ; KAWANO Yuhei 帝京大学, 福岡医療技術学部, 教授 (90118076) ; MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452)
• Co-Investigator(Renkei-kenkyūsha): ASAYAMA Kei 帝京大学, 医学部, 講師 (80431518) ; METOKI Hirohito 東北医科薬科大学, 医学部, 教授 (20580377) ; TOTSUNE Kazuhito 東北福祉大学, 総合マネジメント学部, 教授 (10217515) ; HIROSE Takuo 東北大学, 大学院医学系研究科, 助教 (20599302)
• Research Collaborator: Staessen Jan A.
• Project Period (FY): 2013-05-31 – 2016-03-31
• Keywords: 社会医学 / 循環器・高血圧 / 遺伝子 / 臨床薬理学 / 遺伝子疫学

Outline of Final Research Achievements

We conducted a genome-wide association study regarding blood pressure level, antihypertensive drug effect, and day-to-day blood pressure variability based on self-measured home blood pressure. We collected participant-level individual data from the HOMED-BP trial, Ohasama study, and SONIC study. Genotyping was performed by 500K DNA microarray chips, and genotype imputation was performed with 1000 Genomes dataset (CHB+CHS+JPT) as a reference; we finally obtained >6M single nucleotide polymorphisms (SNPs) for the analysis. Based on the original 500K dataset, SNPs in PICALM, TANC2, NUMA1 and APCDD1 are associated with CCB responses, and those in ABCC9 and YIPF1 are associated with ARB responses. Our study for the first time provided an information on gene polymorphisms relating to home blood pressure such as antihypertensive drug effect, and our approach might be a step in moving towards the personalized treatment of hypertension based on “out-of-office” blood pressure.

Free Research Field

循環器の疫学