Study on pathophysiology of schizophrenia approached from a prototype case

2016 Fiscal Year Final Research Report

• Project/Area Number: 25253074
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: ITOKAWA Masanari 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 病院等連携研究センター長 (40332324)
• Co-Investigator(Kenkyū-buntansha): 吉川 武男 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30249958)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 異種性

Outline of Final Research Achievements

Aim of our study is to clarify the pathology of schizophrenia by detecting a rare mutation with relatively large effect in a prototype case so as to extend it to general polymorphisms. We aimed to elucidate the homogeneous relative small subgroup of schizophrenia sharing a large gene effect since we investigated not based upon the CDCV hypothesis. We extended the prototype with framehift mutation of GLO1 to 40% of the general cases isolated from common cases as a relatively homogeneous pathophysiology called as carbonyl stress. We created model mice that showed deviation of turnover of neurotransmitter. Carbonyl stress was replicated in multiple hospitals.

Free Research Field

精神医学