Development of a PET/OMRI combined system

2017 Fiscal Year Final Research Report

• Project/Area Number: 25253077
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: Yamamoto Seiichi 名古屋大学, 医学系研究科(保健), 教授 (00290768)
• Co-Investigator(Kenkyū-buntansha): 市川 和洋 長崎国際大学, 薬学部, 准教授 (10271115) ; 畑澤 順 大阪大学, 医学系研究科, 教授 (70198745)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: PET / OMRI / combined system / radioactive tracer / free radical / simultaneous imaging

Outline of Final Research Achievements

Positron emission tomography (PET) has high sensitivity for imaging radioactive tracer distributions in subjects. However, it is not possible to image free radical distribution in subject by PET. Since free radicals are quite reactive, they are related to many diseases, including but not limited to cancer, inflammation, strokes, and heart disease. The Overhauser enhanced MRI (OMRI) is so far the only method that images free radical distribution in vivo. By combining PET and OMRI, a new hybrid imaging modality might be developed that can simultaneously image the radioactive tracer and free radical distributions. For this purpose, we developed a PET/OMRI combined system for small animals. Also we tried more sensitive imaging of radical using optical methods.

Free Research Field

放射線計測学