Development of a Y-shaped tissue-engineered artificial trachea for carinal reconstruction.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25253082
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: Nakamura Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 人工気管 / 組織工学 / コラーゲン / 気道再建 / 胸部外科 / 分岐部気管 / 再生 / 生体内再生

Outline of Final Research Achievements

The aim of this study was to develop a tracheal prosthesis for carinal reconstruction. We have studied more than 20years tracheal reconstruction with the base of the concept of in situ Tissue Engineering., where the inner surface is designed to be replased with regenerated host epithelium. Newly developed tracheal prosthesis were evaluated in the animal experiment in terms of feasibility and its safety.

In this project, several types of Y-shaped artificial trachea were manufactured in our laboratory. The material of the tracheal wall were Marlex mesh or bioabsorbable Vicryl mesh.Tracheal bifurcations were reconstructed on 26 beagle adult dogs, Azygos vein was cut, then the tracheal carina was replaced with prosthesis and wrapped the greater omentum. Bronchoscope and CT examinations were performed to evaluate patency of airway and luminal tissue regeneration. These results were now prepared to report on JTCVS.

Free Research Field

呼吸器外科学、人工臓器学、再生医学