西ニューギニア地域の神経変性疾患の実態と予後に関する縦断的研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 25257507
• Research Institution: Kyoto University
• Principal Investigator: 奥宮 清人 京都大学, 東南アジア研究所, 研究員 (20253346)
• Co-Investigator(Kenkyū-buntansha): E.Garcia delSaz 高知大学, 人文社会・教育科学系, 助教 (10294828) ; 大崎 康史 高知大学, 医歯学系, 講師 (20294829) ; 小久保 康昌 三重大学, その他の研究科, その他 (60263000) ; 葛原 茂樹 鈴鹿医療科学大学, 看護学部, 教授 (70111383) ; 松林 公蔵 京都大学, 東南アジア研究所, 教授 (70190494) ; 和田 泰三 京都大学, 東南アジア研究所, その他 (90378646) ; 藤澤 道子 京都大学, 東南アジア研究所, 研究員 (00456782)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: パプア / 筋萎縮性側索硬化症 / パーキンソン症候群 / 西ニューギニア

Outline of Annual Research Achievements

2015年度には、インドネシア、パプア州、マッピ、エデラ川沿いの村、バデ、Ia川流域の村で調査し、新しく診断し得た、神経変性疾患（運動ニューロン疾患、またはパーキンソン症候群）は、認めなかった。フォローアップにより確認し得た死亡者は、5人の運動ニューロン疾患、2人の運動ニューロン疾患とパーキンソン症候群の合併例、1人のパーキンソン症候群であった。生存中の1人の運動ニューロン疾患と6人のパーキンソン症候群をフォローアップし得た。3人の小脳変性症もフォローアップし得た。
グアム島や日本の紀伊半島では、ALSの急激な減少とともにパーキンソン症候群の占める割合の増加が報告された。今回のパプアの調査で、ほとんどの運動ニューロン疾患の方が死亡され、あらたな症例を認めなかった。パプア州においては、生活の近代化が今まさに浸透してきており、時代的な環境変化と高齢化に伴うALSとパーキンソン症候群の病型の変遷が、この地域でも来している可能性が有り、今後も引き続き、フォローアップが必要である。
インドネシア、中央高地のソロバ在住民の調査を来年度に施行するために、打ち合わせを行った。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

10人の神経変性疾患をフォローアップし、8人の死亡を確認し得た。時代的な環境変化と高齢化に伴うALSとパーキンソン症候群の病型の変遷が、この地域でも来している可能性が示唆され、フォローアップの重要性を認識し得た。来年度施行予定の、中央高地のソロバ在住民の調査の打ち合わせを行い、順調に進んでいる。

Strategy for Future Research Activity

今後も、現地のチェンデラワシ大学のスタッフや地域医師、公衆衛生関係者と協力関係を続けながら調査を行い、新症例の確認とともに、生存者のフォローアップ調査と死亡例の確認を継続する。現地でのワークショップや成果の公表と共有をさらに積極的に推進し、治療の可能性あるパーキンソン病やそれ以外の神経変性疾患のＱＯＬ向上に向けて、現地医師の予防や医療の改善に貢献する。

Research Products

• [Int'l Joint Research] Cenderawasih University(Indonesia)
  • Country Name: Indonesia
  • Counterpart Institution: Cenderawasih University
• [Journal Article] Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese. (2016)
  • Author(s): Iwasaki M, Yoshihara A, Kimura Y, Sato M, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Taylor GW, Ansai T, Miyazaki H, Matsubayashi K.
  • Journal Title: J Periodontal Res. Volume: 51 Pages: 681-8.
  • DOI: 10.1111/jre.12348. Epub 2016 Jan 6.
  • Peer Reviewed
• [Journal Article] Health and happiness among community-dwelling older adults in Domkhar valley, Ladakh, India. (2016)
  • Author(s): Sakamoto R, Okumiya K, Norboo T, Tsering N, Wada T, Fujisawa M, Imai H, Nose M, Ishimoto Y, Kimura Y, Fukutomi E, Chen W, Matsubayashi K.
  • Journal Title: Geriatr Gerontol Int. Volume: Epub ahead of print Pages: .
  • DOI: 10.1111/ggi.12745.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Glucose intolerance associated with hypoxia in people living at high altitudes in the Tibetan highland. (2016)
  • Author(s): Okumiya K, Sakamoto R, Ishimoto Y, Kimura Y, Fukutomi E, Ishikawa M, Suwa K, Imai H, Chen W, Kato E, Nakatsuka M, Kasahara Y, Fujisawa M, Wada T, Wang H, Dai Q, Xu H, Qiao H, Ge RL, Norboo T, Tsering N, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Ando K, Inamura T, Takeda S, Ishine M, Otsuka K, Matsubayashi K.
  • Journal Title: BMJ Open. Volume: 6(2) Pages: e009728
  • DOI: 10.1136/bmjopen-2015-009728.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] J-Curve Association Between Glucose Intolerance and Hemoglobin and Ferritin Levels at High Altitude. (2016)
  • Author(s): Okumiya K, Sakamoto R, Ishikawa M, Kimura Y, Fukutomi E, Ishimoto Y, Chen WL, Imai H, Kato E, Kasahara Y, Fujisawa M, Wada T, Ishine M, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Otsuka K, Norboo T, Matsubayashi K.
  • Journal Title: J Am Geriatr Soc. Volume: 64(1) Pages: 207-10.
  • DOI: 10.1111/jgs.13915.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Predictors of difficulty in carrying out basic activities of daily living among the old-old: A 2-year community-based cohort study. (2016)
  • Author(s): Sakamoto R, Okumiya K, Ishine M, Wada T, Fujisawa M, Imai H, Ishimoto Y, Kimura Y, Fukutomi E, Chen W, Sasiwongsaroj K, Kato E, Otsuka K, Matsubayashi K.
  • Journal Title: Geriatr Gerontol Int. Volume: 16(2) Pages: 214-22.
  • DOI: 10.1111/ggi.12462.
  • Peer Reviewed
• [Journal Article] Association between dental status and food diversity among older Japanese. (2015)
  • Author(s): Iwasaki M, Kimura Y, Yoshihara A, Ogawa H, Yamaga T, Takiguchi T, Wada T, Sakamoto R, Ishimoto Y, Fukutomi E, Chen W, Imai H, Fujisawa M, Okumiya K, Manz MC, Miyazaki H, Matsubayashi K.
  • Journal Title: Community Dent Health. Volume: 32(2): Pages: 104-10.
  • Peer Reviewed
• [Journal Article] Oxidized Low Density Lipoprotein Among the Elderly in Qinghai-Tibet Plateau. (2015)
  • Author(s): Sakamoto R, Okumiya K, Wang H, Dai Q, Fujisawa M, Wada T, Imai H, Kimura Y, Ishimoto Y, Fukutomi E, Chen W, Sasiwongsaroj K, Kato E, Ge RL, Matsubayashi K.
  • Journal Title: Wilderness Environ Med. Volume: 26(3) Pages: 343-9
  • DOI: 10.1016/j.wem.2015.03.025.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Depression and Altitude: Cross-Sectional Community-Based Study Among Elderly High-Altitude Residents in the Himalayan Regions. (2015)
  • Author(s): Ishikawa M, Yamanaka G, Yamamoto N, Nakaoka T, Okumiya K, Matsubayashi K, Otsuka K, Sakura H.
  • Journal Title: Cult Med Psychiatry. Volume: 40(1) Pages: 1-11.
  • DOI: 10.1007/s11013-015-9462-7.
  • Peer Reviewed
• [Journal Article] Postcard intervention for depression in community-dwelling older adults: A randomised controlled trial. (2015)
  • Author(s): Imai H, Furukawa TA, Okumiya K, Wada T, Fukutomi E, Sakamoto R, Fujisawa M, Ishimoto Y, Kimura Y, Chen WL, Tanaka M, Matsubayashi K.
  • Journal Title: Psychiatry Res. Volume: 30;229(1-2) Pages: 545-50
  • DOI: 10.1016/j.psychres.2015.05.054.
  • Peer Reviewed
• [Journal Article] Community-based comprehensive geriatric assessment of short- and long-term predictors of cognitive decline in elderly adults. (2015)
  • Author(s): Kikuchi T, Okajima K, Cornelissen G, Sasaki J, Oinuma S, Yamanaka G, Okumiya K, Matsubayashi K, Yamanaka T, Otsuka K.
  • Journal Title: J Am Geriatr Soc. Volume: 63(5) Pages: 1031-3
  • DOI: 10.1111/jgs.13426.
  • Peer Reviewed
• [Journal Article] Prevalence of hypertension at high altitude: cross-sectional survey in Ladakh, Northern India 2007-2011. (2015)
  • Author(s): Norboo T, Stobdan T, Tsering N, Angchuk N, Tsering P, Ahmed I, Chorol T, Kumar Sharma V, Reddy P, Singh SB, Kimura Y, Sakamoto R, Fukutomi E, Ishikawa M, Suwa K, Kosaka Y, Nose M, Yamaguchi T, Tsukihara T, Matsubayashi K, Otsuka K, Okumiya K.
  • Journal Title: BMJ Open. Volume: 5(4) Pages: e007026.
  • DOI: 10.1136/bmjopen-2014-007026.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between risk perception, subjective knowledge, and depression in community-dwelling elderly people in Japan. (2015)
  • Author(s): Imai H, Okumiya K, Fukutomi E, Wada T, Ishimoto Y, Kimura Y, Chen WL, Tanaka M, Sakamoto R, Fujisawa M, Matsubayashi K.
  • Journal Title: Psychiatry Res. Volume: 227(1) Pages: 27-31.
  • DOI: 10.1016/j.psychres.2015.03.002.
  • Peer Reviewed
• [Journal Article] Social cohesion and health in old age: a study in southern Taiwan. (2015)
  • Author(s): Chen W, Okumiya K, Wada T, Sakamoto R, Imai H, Ishimoto Y, Kimura Y, Fukutomi E, Fujisawa M, Shih HI, Chang CM, Matsubayashi K.
  • Journal Title: Int Psychogeriatr. Volume: 27(11) Pages: 1903-11.
  • DOI: 10.1017/S1041610214002907.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Buddhist social networks and health in old age: A study in central Thailand. (2015)
  • Author(s): Sasiwongsaroj K, Wada T, Okumiya K, Imai H, Ishimoto Y, Sakamoto R, Fujisawa M, Kimura Y, Chen WL, Fukutomi E, Matsubayashi K.
  • Journal Title: Geriatr Gerontol Int. Volume: 15(11) Pages: 1210-8.
  • DOI: 10.1111/ggi.12421.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between level of brachial-ankle pulse wave velocity and onset of activities of daily living impairment in community-dwelling older individuals. (2015)
  • Author(s): Kuroiwa Y, Miyano I, Nishinaga M, Takata J, Shimizu Y, Okumiya K, Matsubayashi K, Ozawa T, Kitaoka H, Doi Y, Yasuda N.
  • Journal Title: Geriatr Gerontol Int. Volume: 15(7) Pages: 840-7.
  • DOI: 10.1111/ggi.12356.
  • Peer Reviewed
• [Journal Article] Relationships between each category of 25-item frailty risk assessment (Kihon Checklist) and newly certified older adults under Long-Term Care Insurance: A 24-month follow-up study in a rural community in Japan. (2015)
  • Author(s): Fukutomi E, Okumiya K, Wada T, Sakamoto R, Ishimoto Y, Kimura Y, Chen WL, Imai H, Kasahara Y, Fujisawa M, Otsuka K, Matsubayashi K.
  • Journal Title: Geriatr Gerontol Int. Volume: 15(7) Pages: 864-71
  • DOI: 10.1111/ggi.12360.
  • Peer Reviewed
• [Journal Article] Diagnostic Criteria for Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex in the Kii Peninsula, Japan. (2015)
  • Author(s): Kokubo Y.
  • Journal Title: Brain Nerve. Volume: 67(7) Pages: 961-6
  • DOI: 10.11477/mf.1416200238.
• [Journal Article] CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study. (2015)
  • Author(s): Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
  • Journal Title: Lancet Neurol. Volume: 14(3) Pages: 274-82.
  • DOI: 10.1016/S1474-4422(14)70266-2.
  • Peer Reviewed
• [Presentation] Disease model of amyotrophic lateral sclerosis/ Parkinsonism-Dementia complex in the Kii Peninsula. (2015)
  • Author(s): Kokubo Y
  • Organizer: 26th International Symposium on ALS/MND
  • Place of Presentation: 米国・オーランド
  • Year and Date: 2015-12-11 – 2015-12-13
  • Int'l Joint Research
• [Presentation] Secular Ecological and Aging Transition in Neurodegenerative Diseases in Papua in Indonesia (2015)
  • Author(s): Okumiya K
  • Organizer: International Conference on Social Science & Biodiversity of Papua & Papua New Guinea
  • Place of Presentation: Cenderawasih University
  • Year and Date: 2015-11-16 – 2015-11-17
  • Int'l Joint Research / Invited
• [Presentation] Clinicopathological study of familial ALS/Parkinsonism-Dementia Complex (ALS/PDC) cases in the Kii Peninsula. (2015)
  • Author(s): Kokubo Y
  • Organizer: The XII World Congress of Neurology (WCN 2015)
  • Place of Presentation: チリ・サンチャゴ
  • Year and Date: 2015-10-31 – 2015-11-05
  • Int'l Joint Research
• [Presentation] 地域在住後期高齢者の包括的健康指標の経年的変化 (2015)
  • Author(s): 奥宮清人
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2015-06-12 – 2015-06-14
• [Presentation] 若手のための学術論文の書き方 (2015)
  • Author(s): 奥宮清人
  • Organizer: 第３５回 日本登山医学会学術集会大会
  • Place of Presentation: 高松シンボルタワー（高松市）
  • Year and Date: 2015-05-23 – 2015-05-24
  • Invited
• [Presentation] Follow-up study for neurodegenerative diseases in Papua, Indonesia (2015)
  • Author(s): Okumiya K
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-05-20 – 2015-05-23
• [Remarks] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合、認知症 -Kii ALS/PDC-
  • URL: http://kii-als-pdc-project.com/index.html